Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | CTPS1 | P17812 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962705 | 0.97 | HSD11B1 (0.42) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL4964100 | 0.83 | NMT1 (0.47) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL4965593 | 0.83 | NMT1 (0.44) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL4963612 | 0.78 | KMT2A (0.39) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL4967543 | 0.78 | KMT2A (0.42) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL4966262 | 0.75 | KMT2A (0.40) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL4963210 | 0.75 | TRPV4 (0.40) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL4964602 | 0.75 | KMT2A (0.43) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL4964684 | 0.75 | KMT2A (0.41) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL4963972 | 0.75 | PKM (0.48) | KMT2AMEN1POLBALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |