Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6388614 | 0.93 | OPRM1 (0.38) | OPRM1OPRD1OPRK1TP53GRIN2D | |
| SCHEMBL4964806 | 0.89 | OPRM1 (0.41) | OPRM1OPRD1OPRK1TP53GRIN2D | |
| SCHEMBL4964102 | 0.84 | OPRM1 (0.43) | OPRM1OPRD1OPRK1TP53GRIN2D | |
| SCHEMBL4963415 | 0.83 | NPSR1 (0.49) | GAAMAPTMAPK1NPSR1L3MBTL1 | |
| SCHEMBL4964748 | 0.83 | CARM1 (0.43) | OPRM1OPRD1OPRK1MAPTMAPK1 | |
| SCHEMBL4965187 | 0.83 | MAPT (0.38) | OPRM1OPRD1OPRK1SLC6A2SLC6A3 | |
| SCHEMBL14132128 | 0.81 | OPRM1 (0.67) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4963822 | 0.81 | P2RX3 (0.45) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4963716 | 0.81 | LTA4H (0.55) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4963704 | 0.79 | OPRM1 (0.43) | OPRM1OPRD1OPRK1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606275-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-27 | — | — | EP | claimed |
| US-20060166987-A1 | Opioid receptor antagonists | ELI LILLY AND COMPANY | 2006-07-27 | — | — | US | claimed |
| EP-1606275-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-12-21 | — | — | EP | claimed |
| WO-2004080996-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2004-09-23 | — | — | WO | claimed |
| EP-1606275-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-27 | — | — | EP | disclosed |
| US-7396943-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| US-7396943-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| US-7396943-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| US-20060166987-A1 | Opioid receptor antagonists | ELI LILLY AND COMPANY | 2006-07-27 | — | — | US | disclosed |
| EP-1606275-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004080996-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166987-A1 | Opioid receptor antagonists | OPRM1, OPRD1, OPRK1 | OPRM1 1/4885OPRD1 2/4885OPRK1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.