SCHEMBL496623

SCHEMBL496623

O=C(O)c1ccccc1-c1ccc(Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 1/20 0.64
SLC6A3 Q01959 1/20 0.64
NR4A1 P22736 1/20 0.56
BRS3 P32247 1/20 0.54
LTB4R2 Q9NPC1 3/20 0.53
HNF4A P41235 1/20 0.53
KDM4E B2RXH2 2/20 0.53
RAB9A P51151 2/20 0.53
ALDH1A1 P00352 5/20 0.52
BCAT2 O15382 1/20 0.52
CYP1A2 P05177 2/20 0.50
FTO Q9C0B1 1/20 0.50
ALOX15 P16050 1/20 0.50
CYP3A4 P08684 1/20 0.50
GAA P10253 1/20 0.50
ALOX12 P18054 1/20 0.50
CYP2C19 P33261 1/20 0.50
CTRC Q99895 1/20 0.49
FABP3 P05413 1/20 0.49
FABP4 P15090 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30292805 0.89 HNF4A (0.63) LTB4R2HNF4AKDM4ERAB9AALDH1A1
SCHEMBL18759613 0.89 HNF4A (0.63) LTB4R2HNF4AKDM4ERAB9AALDH1A1
SCHEMBL11554621 0.87 HNF4A (0.61) SLC6A3LTB4R2HNF4ARAB9AALDH1A1
SCHEMBL10631889 0.86 SLC6A4 (0.66) SLC6A4SLC6A3NR4A1BRS3BCAT2
SCHEMBL505412 0.85 HNF4A (0.64) BRS3LTB4R2HNF4ARAB9AALDH1A1
SCHEMBL32677769 0.85 HNF4A (0.64) BRS3LTB4R2HNF4ARAB9AALDH1A1
SCHEMBL32677772 0.85 HNF4A (0.64) BRS3LTB4R2HNF4ARAB9AALDH1A1
SCHEMBL133057 0.85 HNF4A (0.69) LTB4R2HNF4AKDM4ERAB9AALDH1A1
Benzene SCHEMBL1403559 0.85 HNF4A (0.69) LTB4R2HNF4AKDM4ERAB9AALDH1A1
Benzene SCHEMBL28480917 0.85 HNF4A (0.69) LTB4R2HNF4AKDM4ERAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120025244-A Synthesis method of 2- (4' -chlorophenyl) benzoic acid 浙江工业大学 2025-05-23 CN claimed
CN-109232411-B Method for preparing boscalid 广东广康生化科技股份有限公司 2021-10-01 CN claimed
CN-111662184-A Synthetic method of boscalid intermediate 2- (4' -chlorphenyl) aniline 广东广康生化科技股份有限公司 2020-09-15 CN claimed
CN-109232411-A A method of preparing boscalid 广东广康生化科技股份有限公司 2019-01-18 CN claimed
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists BAYER AKTIENGESELLSCHAFT (DE) 2025-08-26 US disclosed
CN-120025244-A Synthesis method of 2- (4' -chlorophenyl) benzoic acid 浙江工业大学 2025-05-23 CN disclosed
CN-120025244-A Synthesis method of 2- (4' -chlorophenyl) benzoic acid 浙江工业大学 2025-05-23 CN disclosed
CN-120025244-A Synthesis method of 2- (4' -chlorophenyl) benzoic acid 浙江工业大学 2025-05-23 CN disclosed
EP-4058448-B1 HYDANTOIN DERIVATIVES AS ADAMTS7 ANTAGONISTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES BAYER AG (DE) 2024-05-29 EP disclosed
CN-115286514-B Preparation method of 4' -chloro-2-aminobiphenyl sulfate 山东京博农化科技股份有限公司 2024-01-12 CN disclosed
US-20230027346-A1 SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS BAYER AKTIENGESELLSCHAFT (DE) 2023-01-26 US disclosed
CN-115286514-A Preparation method of 4' -chloro-2-aminobiphenyl sulfate 京博农化科技有限公司 2022-11-04 CN disclosed
EP-1283055-A1 SOLUBLE BETA AMYLOID PRECURSOR PROTEIN SECRETION PROMOTERS Takeda Chemical Industries, Ltd. (JP) 2003-02-12 EP disclosed
WO-2002028835-A1 BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-04-11 WO disclosed
EP-1138712-A2 Polyarylene copolymers and proton-conductive membrane JSR Corporation (JP) 2001-10-04 EP disclosed
US-5580741-A INCUBATING SAMPLE SOLUTION IN CONTAINER PRECOATED WITH ANTIBODY AND PROTEIN CONJUGATE YIELDS COMPLEXES, THEN REMOVAL AND REACTION WITH CHEMILUMINESCENT REAGENTS FOR MEASUREMENT OF LIGHT INTENSITY, FOR CHLORINATED BIPHENYLS GENERAL ELECTRIC COMPANY (US) 1996-12-03 US disclosed
US-5466858-A Ruthenium catalyst, high selectivity with a carboxylic acid UBE INDUSTRIES, LTD. (JP) 1995-11-14 US disclosed
EP-0059983-B1 SUBSTITUTED BIPHENYL COMPOUNDS FOR USE AS A MEDICAMENT THE WELLCOME FOUNDATION LIMITED (GB) 1986-06-11 EP disclosed
US-4578522-A CHEMICAL INTERMEDIATES FOR BLOOD LIPID CONTROLLING COMPOUNDS BURROUGHS WELLCOME CO. 1986-03-25 US disclosed
EP-0059983-A1 Substituted biphenyl compounds for use as a medicament THE WELLCOME FOUNDATION LIMITED (GB) 1982-09-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists ADAMTS7, MMP7, ADAM17 SLC6A4 1821/4885SLC6A3 1469/4885NR4A1 2906/4885
US-20230027346-A1 SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS ADAMTS7, MMP7, ADAM17 SLC6A4 1821/4885SLC6A3 1469/4885NR4A1 2906/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.