Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969422 | 0.87 | F2 (0.50) | NR1I2MEN1KMT2ALMNAMAPT | |
| SCHEMBL7750649 | 0.73 | DCTPP1 (0.41) | LMNAMAPTCYP1A2CYP2C9CNR1 | |
| SCHEMBL8927745 | 0.72 | SLC2A1 (0.43) | MEN1KMT2ALMNAMAPTCYP1A2 | |
| SCHEMBL615353 | 0.69 | KDM4E (0.57) | NR1I2MEN1KMT2ALMNAMAPT | |
| SCHEMBL618667 | 0.69 | NR1I2 (0.56) | NR1I2MEN1KMT2AMAPTPPARG | |
| SCHEMBL617197 | 0.68 | PKM (0.44) | NR1I2MEN1KMT2AHIF1ALMNA | |
| SCHEMBL13106647 | 0.66 | MEN1 (0.57) | NR1I2PTPN2PTPN1PTPN5MEN1 | |
| SCHEMBL617578 | 0.65 | HSD11B1 (0.45) | NR1I2MEN1KMT2ALMNA | |
| SCHEMBL622613 | 0.65 | KMT2A (0.52) | NR1I2KMT2AMAPT | |
| SCHEMBL13248536 | 0.65 | HSD11B1 (0.45) | NR1I2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670790-B1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | claimed |