Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1393022 | 0.75 | ALDH1A1 (0.39) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL21570231 | 0.71 | ALDH1A1 (0.37) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL20346931 | 0.70 | ATM (0.38) | ALDH1A1NPC1TSHRSMN1; SMN2MAPT | |
| SCHEMBL25318763 | 0.67 | RAB9A (0.45) | KMT2AMEN1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL22279544 | 0.67 | MAPT (0.42) | KMT2AMEN1ALDH1A1POLBTSHR | |
| SCHEMBL14704043 | 0.66 | DRD3 (0.39) | KMT2AMEN1ALDH1A1NPC1MAPT | |
| SCHEMBL13394781 | 0.64 | DRD3 (0.38) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL21570233 | 0.64 | SMN1; SMN2 (0.41) | KMT2AALDH1A1NPC1POLBTSHR | |
| SCHEMBL942185 | 0.64 | LMNA (0.33) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL17360810 | 0.63 | PGR (0.40) | KMT2AMEN1TSHRSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778685-B1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SANOL ARZNEI SCHWARZ GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1778685-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015737-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2006-02-16 | — | — | WO | disclosed |