Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968337 | 0.84 | MAPT (0.44) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL4970714 | 0.83 | MEN1 (0.40) | L3MBTL1ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL5513518 | 0.80 | MEN1 (0.45) | ALDH1A1MEN1KMT2AHSD17B10HPGD | |
| SCHEMBL4972027 | 0.74 | MAPT (0.46) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL25104929 | 0.73 | KDM4E (0.44) | KDM4EL3MBTL1ATMALDH1A1MEN1 | |
| SCHEMBL11940495 | 0.72 | CA1 (0.54) | KDM4EL3MBTL1ATMALDH1A1MEN1 | |
| SCHEMBL7427782 | 0.71 | CA1 (0.55) | KDM4EL3MBTL1ATMALDH1A1MEN1 | |
| SCHEMBL4968907 | 0.71 | HTR6 (0.41) | ALDH1A1MEN1KMT2AHSD17B10TBXA2R | |
| SCHEMBL19311768 | 0.71 | ALDH1A1 (0.36) | KDM4EL3MBTL1ATMALDH1A1MEN1 | |
| SCHEMBL4966957 | 0.71 | KDM4E (0.45) | KDM4EALDH1A1MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654228-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | claimed |