Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 3/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.36 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966863 | 0.98 | RAB9A (0.45) | NOTUMRAB9AKMOSMN1; SMN2EPHX2 | |
| SCHEMBL6209027 | 0.93 | NOTUM (0.46) | NOTUMRAB9AKMOSMN1; SMN2KDM4A | |
| SCHEMBL4969319 | 0.84 | NOTUM (0.39) | NOTUMRAB9AKMOSMN1; SMN2EPHX2 | |
| SCHEMBL4965859 | 0.82 | KMO (0.43) | KMO | |
| SCHEMBL4967987 | 0.78 | AKR1C3 (0.44) | NOTUMKMO | |
| SCHEMBL31702895 | 0.78 | CDC7 (0.38) | SMN1; SMN2DAOCDK2 | |
| SCHEMBL11374138 | 0.72 | KDM4E (0.50) | RAB9AKMOSMN1; SMN2ACMSDHCAR2 | |
| SCHEMBL14273035 | 0.69 | GAA (0.52) | KMOKDM5AACMSD | |
| SCHEMBL28170978 | 0.69 | CAMKK2 (0.52) | KMOCAMKK2CAMKK1ACMSD | |
| SCHEMBL1173489 | 0.69 | KMO (0.44) | KMOCAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954693-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062007-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |