Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 2/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969223 | 0.84 | NOTUM (0.43) | NOTUMRAB9ASMN1; SMN2KMOHCAR2 | |
| SCHEMBL4966863 | 0.83 | RAB9A (0.45) | NOTUMRAB9ASMN1; SMN2KMOKDM4A | |
| SCHEMBL4965859 | 0.82 | KMO (0.43) | RARGRARBKMOMEN1ALDH1A1 | |
| SCHEMBL6209027 | 0.81 | NOTUM (0.46) | NOTUMRARGRARBRAB9ASMN1; SMN2 | |
| SCHEMBL4967987 | 0.76 | AKR1C3 (0.44) | NOTUMRARGRARBKMOMEN1 | |
| SCHEMBL31702895 | 0.67 | CDC7 (0.38) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28794370 | 0.66 | HRH4 (0.39) | MEN1ALDH1A1KMT2A | |
| SCHEMBL28016809 | 0.65 | KDM4E (0.44) | NOTUMKMOMEN1ALDH1A1KMT2A | |
| SCHEMBL31702908 | 0.64 | NNMT (0.36) | NOTUMALDH1A1 | |
| SCHEMBL480033 | 0.64 | NOTUM (0.63) | NOTUMSMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954693-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062007-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |