Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL516285 | 0.96 | TSHR (0.34) | TSHR | |
| Acrylamide SCHEMBL4970338 | 0.85 | TSHR (0.42) | TSHR | |
| Acrylamide SCHEMBL516286 | 0.81 | TSHR (0.42) | TSHR | |
| Acrylamide SCHEMBL10805786 | 0.78 | TSHR (0.35) | TSHR | |
| Potassium Ion SCHEMBL18008192 | 0.78 | — | — | |
| Acrylamide SCHEMBL5057257 | 0.78 | TSHR (0.39) | TSHR | |
| SCHEMBL7587889 | 0.73 | GRIA1 (0.35) | — | |
| Lithium Ion SCHEMBL18008587 | 0.73 | — | — | |
| SCHEMBL6965603 | 0.73 | TP53 (0.30) | — | |
| SCHEMBL125161 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133774-B9 | FIBER COATED WITH WATER BLOCKING MATERIAL | DU PONT (US) | 2008-08-13 | — | — | EP | claimed |
| EP-1133774-B1 | FIBER COATED WITH WATER BLOCKING MATERIAL | DU PONT (US) | 2007-08-29 | — | — | EP | claimed |
| US-20030124350-A1 | Fiber coated with water blocking material | REBOUILLAT SERGE (FR) | 2003-07-03 | — | — | US | claimed |
| US-6586094-B1 | Fiber coated with water blocking material | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-07-01 | — | — | US | claimed |
| EP-1133774-A2 | FIBER COATED WITH WATER BLOCKING MATERIAL | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2001-09-19 | — | — | EP | claimed |
| WO-2000031752-A9 | FIBER COATED WITH WATER BLOCKING MATERIAL | DU PONT (US) | 2001-05-17 | — | — | WO | claimed |
| WO-2000031752-A2 | FIBER COATED WITH WATER BLOCKING MATERIAL | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-06-02 | — | — | WO | claimed |
| EP-1133774-B9 | FIBER COATED WITH WATER BLOCKING MATERIAL | DU PONT (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1133774-B1 | FIBER COATED WITH WATER BLOCKING MATERIAL | DU PONT (US) | 2007-08-29 | — | — | EP | disclosed |
| US-6891003-B2 | Fiber coated with water blocking material | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2005-05-10 | — | — | US | disclosed |
| US-20030124350-A1 | Fiber coated with water blocking material | REBOUILLAT SERGE (FR) | 2003-07-03 | — | — | US | disclosed |
| US-6586094-B1 | Fiber coated with water blocking material | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-07-01 | — | — | US | disclosed |
| EP-1133774-A2 | FIBER COATED WITH WATER BLOCKING MATERIAL | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000031752-A9 | FIBER COATED WITH WATER BLOCKING MATERIAL | DU PONT (US) | 2001-05-17 | — | — | WO | disclosed |
| WO-2000031752-A2 | FIBER COATED WITH WATER BLOCKING MATERIAL | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-06-02 | — | — | WO | disclosed |