Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 4/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823949 | 0.87 | AQP1 (0.31) | MAPTTDP1 | |
| SCHEMBL4596468 | 0.80 | ALDH1A1 (0.42) | DRD2ALDH1A1MAPTMAOBF2RL3 | |
| SCHEMBL4596465 | 0.79 | ALDH1A1 (0.37) | DRD2ALDH1A1MAPTMAOBF2RL3 | |
| SCHEMBL4222368 | 0.78 | PRKAB2 (0.51) | DRD2ALDH1A1MAPTMAOBF2RL3 | |
| SCHEMBL5148557 | 0.77 | DRD2 (0.38) | DRD2ALDH1A1MAPTMAOBF2RL3 | |
| SCHEMBL4226625 | 0.76 | PRKAB2 (0.42) | DRD2ALDH1A1MAPTMAOBF2RL3 | |
| SCHEMBL4226616 | 0.76 | AQP1 (0.45) | DRD2ALDH1A1MAPTMAOBF2RL3 | |
| SCHEMBL4970746 | 0.75 | AQP1 (0.46) | ALDH1A1F2RL3MAPK1HSD17B10 | |
| SCHEMBL4836377 | 0.75 | AQP1 (0.36) | ALDH1A1MAPTMAPK1HTTTDP1 | |
| SCHEMBL6047897 | 0.72 | GSK3B (0.38) | DRD2ALDH1A1MAPTMAOBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871354-A1 | TREATMENT OF PAIN | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116171-A1 | TREATMENT OF PAIN | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |