Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.58 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.54 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.54 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.54 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1307939 | 0.82 | HDAC1 (0.65) | KCNMA1KCNK3KCNK9HDAC1HDAC8 | |
| SCHEMBL403235 | 0.82 | MEN1 (0.68) | KCNMA1KCNK3KCNK9HDAC1HDAC8 | |
| SCHEMBL14007286 | 0.79 | KCNMA1 (0.71) | KCNMA1KCNK3KCNK9KCNQ3KCNQ2 | |
| SCHEMBL399870 | 0.78 | MEN1 (0.68) | KCNMA1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8819672 | 0.76 | MEN1 (0.82) | KCNMA1HDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL3675463 | 0.76 | KCNK3 (0.84) | KCNK3KCNK9KCNQ3KCNQ2KCNE1 | |
| SCHEMBL402589 | 0.76 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| Iodide SCHEMBL30758629 | 0.75 | MEN1 (0.80) | KCNMA1HDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL3786882 | 0.74 | KCNK3 (0.87) | KCNK3KCNK9HDAC1HDAC8HDAC6 | |
| SCHEMBL3674558 | 0.74 | KCNK3 (0.71) | KCNMA1KCNK3KCNK9KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |