SCHEMBL497657

SCHEMBL497657

C[C@]12CCCC[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)O)CC[C@@H]12

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
AKR1B10 O60218 2/20 0.58
AKR1B1 P15121 2/20 0.58
LMNA P02545 2/20 0.58
EFNA1 P20827 1/20 0.58
EPHA2 P29317 1/20 0.58
PSEN1 P49768 1/20 0.58
PSEN2 P49810 1/20 0.58
GPBAR1 Q8TDU6 1/20 0.58
APH1B Q8WW43 1/20 0.58
NCSTN Q92542 1/20 0.58
APH1A Q96BI3 1/20 0.58
PSENEN Q9NZ42 1/20 0.58
HSD17B10 Q99714 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
GABRP O00591 4/20 0.54
GABRD O14764 4/20 0.54
GABRA1 P14867 4/20 0.54
GABRB1 P18505 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6045004 1.00 MEN1 (0.58) MEN1KMT2AAKR1B10AKR1B1LMNA
SCHEMBL497658 1.00 MEN1 (0.58) MEN1KMT2AAKR1B10AKR1B1LMNA
SCHEMBL13988189 1.00 MEN1 (0.58) MEN1KMT2AAKR1B10AKR1B1LMNA
SCHEMBL11060164 1.00 MEN1 (0.58) MEN1KMT2AAKR1B10AKR1B1LMNA
SCHEMBL11345742 1.00 MEN1 (0.58) MEN1KMT2AAKR1B10AKR1B1LMNA
SCHEMBL6044996 1.00 MEN1 (0.58) MEN1KMT2AAKR1B10AKR1B1LMNA
SCHEMBL11696291 0.90 MEN1 (0.57) MEN1KMT2AAKR1B10AKR1B1LMNA
Acetic Acid SCHEMBL29519885 0.89 GABRP (0.66) MEN1KMT2AAKR1B10AKR1B1LMNA
SCHEMBL23872369 0.89 GABRA1 (0.69) MEN1KMT2AAKR1B10AKR1B1LMNA
SCHEMBL598324 0.89 GABRA1 (0.69) MEN1KMT2AAKR1B10AKR1B1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070259837-A1 Use of Non-Glucocorticoid Steroids for the Treatment of Muscular Dystrophy SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) 2007-11-08 US claimed
EP-1776122-A1 USE OF NON-GLUCOCORTICOID STEROIDS FOR THE TREATMENT OF MUSCULAR DYSTROPHY Santhera Pharmaceuticals (Schweiz) AG (CH) 2007-04-25 EP claimed
WO-2006007910-A1 USE OF NON-GLUCOCORTICOID STEROIDS FOR THE TREATMENT OF MUSCULAR DYSTROPHY SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) 2006-01-26 WO claimed
EP-1618881-A1 Use of non-glucocorticoid steroids for the treatment of muscular dystrophy Santhera Pharmaceuticals (Schweiz) GmbH (CH) 2006-01-25 EP claimed
US-4171352-A Quantitative evaluation of enteric microbial overgrowth POLYSCIENCES, INC. (US) 1979-10-16 US claimed
US-20260130889-A1 MICROTUBULE POLYMERIZATION INHIBITOR PRODRUGS AND METHODS OF USING THE SAME UNIV MARYLAND (US) 2026-05-14 US disclosed
US-12433873-B2 Microtubule polymerization inhibitor prodrugs and methods of using the same UNIVERSITY OF MARYLAND, BALTIMORE (US) 2025-10-07 US disclosed
EP-4403171-A2 MICROTUBULE POLYMERIZATION INHIBITOR PRODRUGS AND METHODS OF USING THE SAME University of Maryland, Baltimore (US) 2024-07-24 EP disclosed
US-20240099955-A1 SKINCARE COMPOSITIONS AND METHODS OF USE THEREOF HTL BIOTECHNOLOGY INNOVATION INC. 2024-03-28 US disclosed
EP-3641741-B1 MICROTUBULE POLYMERIZATION INHIBITOR PRODRUGS AND METHODS OF USING THE SAME UNIV MARYLAND (US) 2024-03-20 EP disclosed
EP-4288084-A1 SKINCARE COMPOSITIONS AND METHODS OF USE THEREOF Modern Meadow, Inc. (US) 2023-12-13 EP disclosed
US-20230241034-A1 MICROTUBULE POLYMERIZATION INHIBITOR PRODRUGS AND METHODS OF USING THE SAME UNIV MARYLAND (US) 2023-08-03 US disclosed
EP-0004741-A3 THIO ETIANIC ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE 1979-11-14 EP disclosed
EP-0004772-A2 4-Halo etianic acids and derivatives thereof, their pharmaceutical use and preparation SYNTEX (U.S.A.) INC. (US) 1979-10-17 EP disclosed
EP-0004741-A2 Thio etianic acid derivatives, their preparation and pharmaceutical use SYNTEX (U.S.A.) INC. (US) 1979-10-17 EP disclosed
EP-0004741-A2 Thio etianic acid derivatives, their preparation and pharmaceutical use SYNTEX (U.S.A.) INC. (US) 1979-10-17 EP disclosed
EP-0004741-A2 Thio etianic acid derivatives, their preparation and pharmaceutical use SYNTEX (U.S.A.) INC. (US) 1979-10-17 EP disclosed
US-4171352-A Quantitative evaluation of enteric microbial overgrowth POLYSCIENCES, INC. (US) 1979-10-16 US disclosed
US-4104285-A OF NORCHOLANIC ACID, BISNORCHOLANIC ACID, OR ETIOCHOLANIC ACID, STEROIDS, BILE FLOW STIMULATORS, ANTILIPEMIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1978-08-01 US disclosed
US-3933791-A Obtention of digitoxigenin from neriifolin and 2'-acetylneriifolin SYNTEX (U.S.A.) INC. (US) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070259837-A1 Use of Non-Glucocorticoid Steroids for the Treatment of Muscular Dystrophy UTRN, MTPN, NR3C1 MEN1 2826/4885KMT2A 4662/4885AKR1B10 2675/4885
US-12433873-B2 Microtubule polymerization inhibitor prodrugs and methods of using the same TUBA1C, TUBB3, TUBB MEN1 2488/4885KMT2A 2394/4885AKR1B10 2391/4885
US-20230241034-A1 MICROTUBULE POLYMERIZATION INHIBITOR PRODRUGS AND METHODS OF USING THE SAME TUBA1C, TUBB3, TUBB MEN1 2488/4885KMT2A 2394/4885AKR1B10 2391/4885
US-20260130889-A1 MICROTUBULE POLYMERIZATION INHIBITOR PRODRUGS AND METHODS OF USING THE SAME TUBB3, TUBB1, TUBB MEN1 4397/4885KMT2A 3703/4885AKR1B10 1374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.