Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29718608 | 1.00 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1LPAR1GABRA1GABRB2 | |
| SCHEMBL20681290 | 0.84 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1GABRA1GABRB2SLC6A2 | |
| SCHEMBL2554055 | 0.82 | AKR1B1 (0.55) | LPAR1GABRA1GABRB2LMNACYP1A2 | |
| SCHEMBL9272837 | 0.82 | LPAR1 (0.46) | LPAR1GABRA1GABRB2SLC6A2SLC6A4 | |
| SCHEMBL10864953 | 0.82 | L3MBTL1 (0.46) | LPAR1GABRA1GABRB2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL10582878 | 0.81 | AKR1B1 (0.53) | LPAR1GABRA1GABRB2LMNACYP1A2 | |
| SCHEMBL29718697 | 0.81 | NPSR1 (0.36) | HSP90AA1HSP90AB1SLC6A3LMNACA2 | |
| SCHEMBL17975834 | 0.79 | LPAR1 (0.44) | LPAR1GABRA1GABRB2SLC6A2SLC6A4 | |
| SCHEMBL10339218 | 0.79 | AKR1B1 (0.46) | CA2CYP1A2CYP3A4TSHRBLM | |
| SCHEMBL2817756 | 0.78 | GABRA1 (0.55) | HSP90AA1HSP90AB1LPAR1GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210188869-A1 | INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2021-06-24 | — | — | US | disclosed |
| US-10927125-B2 | Substituted cinnolines as inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2021-02-23 | — | — | US | disclosed |
| EP-3458443-B1 | AROMATIC SULFONAMIDE DERIVATIVES | Bayer Pharma AG (DE) | 2020-08-19 | — | — | EP | disclosed |
| US-20200102321-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2020-04-02 | — | — | US | disclosed |
| CN-106572658-B | Molecule and relative intermediate, composition and method with certain disinsection efficiencies | 美国陶氏益农公司 | 2019-11-08 | — | — | CN | disclosed |
| CN-110372530-A | A kind of compound of the structure of substituted-phenyl containing α and preparation method thereof and elimination agent | 郑州大学 | 2019-10-25 | — | — | CN | disclosed |
| CN-109788759-A | Pesticidal combination and method | 美国陶氏益农公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-106572658-A | Molecules having certain pesticidal utilities, and intermediates, compositions, and processes related thereto | 美国陶氏益农公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-104936954-A | compounds and methods of use thereof | AGIOS PHARMACEUTICALS INC | 2015-09-23 | — | — | CN | disclosed |
| US-20130289083-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION | 2013-10-31 | — | — | US | disclosed |
| US-20110053941-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-03-03 | — | — | US | disclosed |
| US-7388111-B2 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2008-06-17 | — | — | US | disclosed |
| US-20070088053-A1 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC | 2007-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188869-A1 | INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | HSP90AA1 4244/4885HSP90AB1 3687/4885LPAR1 646/4885 |
| US-10927125-B2 | Substituted cinnolines as inhibitors of KRAS G12C | KRAS, NRAS, HRAS | HSP90AA1 4699/4885HSP90AB1 4318/4885LPAR1 1650/4885 |
| US-20110053941-A1 | IDO Inhibitors | IDO1, IDO2, INMT | HSP90AA1 3786/4885HSP90AB1 3086/4885LPAR1 3228/4885 |
| US-20200102321-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | HSP90AA1 4248/4885HSP90AB1 3884/4885LPAR1 1615/4885 |
| US-20070088053-A1 | Non-nucleoside reverse transcriptase inhibitors | SAMHD1, QTRT1, RTF1 | HSP90AA1 2699/4885HSP90AB1 2414/4885LPAR1 1478/4885 |
| US-20130289083-A1 | IDO Inhibitors | IDO1, IDO2, INMT | HSP90AA1 3139/4885HSP90AB1 2435/4885LPAR1 3480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.