Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL16581715 | 0.94 | TBXAS1 (0.34) | IDO1CYP11B1CYP11B2CYP19A1CYP2A6 | |
| SCHEMBL14964291 | 0.90 | IDO1 (0.39) | IDO1CYP19A1 | |
| SCHEMBL14964196 | 0.89 | IDO1 (0.32) | IDO1 | |
| SCHEMBL14964273 | 0.85 | ALOX15 (0.40) | IDO1 | |
| SCHEMBL16581716 | 0.83 | WDR5 (0.34) | IDO1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL14462395 | 0.82 | MEN1 (0.40) | CYP11B1CYP11B2CYP19A1CYP2A6CYP2B6 | |
| SCHEMBL14964338 | 0.81 | IDO1 (0.35) | IDO1 | |
| SCHEMBL14964339 | 0.80 | MAPK1 (0.32) | IDO1 | |
| SCHEMBL14964328 | 0.80 | IDO1 (0.37) | IDO1 | |
| SCHEMBL14964261 | 0.79 | CYP2A13 (0.37) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |
| EP-1971583-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | Incyte Corporation (US) | 2008-09-24 | — | — | EP | claimed |
| WO-2007075598-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |