Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749414 | 0.79 | CES2 (0.48) | RAB9AMAPTLMNANPC1SRD5A2 | |
| SCHEMBL418246 | 0.77 | HDAC1 (0.67) | HDAC1RAB9AMAPTLMNANPC1 | |
| SCHEMBL3370090 | 0.76 | HTT (0.50) | HDAC1RAB9AMAPTALOX12LMNA | |
| SCHEMBL4192188 | 0.76 | NPC1 (0.48) | HDAC1RAB9AMAPTLMNANPC1 | |
| Hydrochloric Acid SCHEMBL28941790 | 0.75 | HDAC1 (0.64) | HDAC1RAB9AMAPTLMNANPC1 | |
| SCHEMBL10871615 | 0.74 | HDAC1 (0.52) | HDAC1RAB9AMAPTALOX12LMNA | |
| SCHEMBL28470795 | 0.73 | NPC1 (0.60) | RAB9AMAPTALOX12LMNANPC1 | |
| SCHEMBL8648310 | 0.73 | SRD5A2 (0.54) | HDAC1RAB9AMAPTALOX12LMNA | |
| SCHEMBL11699186 | 0.73 | MAPT (0.50) | HDAC1RAB9AMAPTALOX12LMNA | |
| SCHEMBL462576 | 0.72 | IDO1 (0.58) | RAB9AMAPTALOX12LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125469-A1 | Thiadiazole compounds and methods of use thereof | WYETH (US) | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125469-A1 | Thiadiazole compounds and methods of use thereof | ADAMTS5, ADAMTS1, TIMP3 | HDAC1 1226/4885RAB9A 2706/4885MAPT 1320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.