Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.63 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CLK1 | P49759 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5006955 | 0.87 | CLK1 (0.62) | PLK1TAS1R3TAS1R1CLK1MAPK1 | |
| SCHEMBL31425751 | 0.87 | PLK1 (0.66) | PLK1TAS1R3TAS1R1LMNAALDH1A1 | |
| SCHEMBL30025133 | 0.87 | PLK1 (0.66) | PLK1TAS1R3TAS1R1LMNAALDH1A1 | |
| SCHEMBL5007649 | 0.85 | ROCK2 (0.63) | TAS1R3TAS1R1MAPK1ROCK2RPS6KA5 | |
| SCHEMBL4984488 | 0.84 | ALDH1A1 (0.65) | PLK1TAS1R3TAS1R1LMNAALDH1A1 | |
| SCHEMBL4981855 | 0.81 | S1PR2 (0.67) | PLK1TAS1R3TAS1R1LMNAALDH1A1 | |
| SCHEMBL5010043 | 0.81 | TAS1R3 (0.59) | PLK1TAS1R3TAS1R1LMNAALDH1A1 | |
| SCHEMBL5006937 | 0.80 | ALDH1A1 (0.55) | PLK1TAS1R3TAS1R1LMNAALDH1A1 | |
| SCHEMBL16735576 | 0.80 | ALDH1A1 (0.56) | LMNAALDH1A1CLK1MAPK1MEN1 | |
| SCHEMBL5661493 | 0.80 | NPC1 (0.67) | LMNAALDH1A1SMN1; SMN2CLK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393958-B2 | Triamide-substituted heterobicyclic compounds | PFIZER, INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-20070093525-A1 | Triamide-substituted heterobicyclic compounds | PFIZER INC | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093525-A1 | Triamide-substituted heterobicyclic compounds | APOB, MTPN, CTRB1 | PLK1 4757/4885TAS1R3 415/4885TAS1R1 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.