Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10587406 | 0.87 | GABRA1 (0.53) | ALDH1A1HPGDHSD17B10GABRA1GABRB2 | |
| SCHEMBL8627011 | 0.86 | AKR1B1 (0.46) | ALDH1A1HPGDBCL2L1HSD17B10GABRA1 | |
| SCHEMBL1354945 | 0.81 | GABRA1 (0.48) | ALDH1A1HPGDHSD17B10GABRA1GABRB2 | |
| SCHEMBL28947809 | 0.81 | AKR1B1 (0.45) | ALDH1A1HPGDBCL2L1HSD17B10GABRA1 | |
| SCHEMBL69556 | 0.80 | GABRA1 (0.48) | ALDH1A1HPGDHSD17B10GABRA1GABRB2 | |
| SCHEMBL2362467 | 0.80 | GABRA1 (0.52) | ALDH1A1HPGDBCL2L1HSD17B10GABRA1 | |
| SCHEMBL15106928 | 0.80 | GABRA1 (0.39) | ALDH1A1HPGDBCL2L1HSD17B10GABRA1 | |
| Phenol SCHEMBL27814865 | 0.79 | GLA (0.44) | ALDH1A1HPGDGABRA1GABRB2MEN1 | |
| SCHEMBL11780256 | 0.79 | AKR1B1 (0.41) | ALDH1A1HPGDBCL2L1HSD17B10GABRA1 | |
| SCHEMBL9197925 | 0.79 | AKR1B1 (0.71) | ALDH1A1HPGDGABRA1GABRB2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210346495-A1 | METHODS AND COMPOSITIONS COMPRISING AN NFKB INHIBITOR AND AN ADJUVANT | THE UNIVERSITY OF CHICAGO (US) | 2021-11-11 | — | — | US | disclosed |
| WO-2020118159-A1 | METHODS AND COMPOSITIONS COMPRISING AN NFKB INHIBITOR AND AN ADJUVANT | THE UNIVERSITY OF CHICAGO (US) | 2020-06-11 | — | — | WO | disclosed |
| EP-3097409-A1 | METHOD FOR ACCELERATED DEGRADATION OF THERMOPLASTICS | SABIC Global Technologies B.V. (NL) | 2016-11-30 | — | — | EP | disclosed |
| WO-2015112143-A1 | METHOD FOR ACCELERATED DEGRADATION OF THERMOPLASTICS | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2015-07-30 | — | — | WO | disclosed |
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1847535-A1 | 1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2007-10-24 | — | — | EP | disclosed |
| EP-1847535-A1 | 1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2007-10-24 | — | — | EP | disclosed |
| US-5741438-A | Optically active biphenyl derivative, process for preparation thereof, liquid crystal composition containing the same as an effective component, and liquid crystal element using the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-04-21 | — | — | US | disclosed |
| EP-0395390-B1 | Optically active biphenyl derivative, process for preparation thereof, liquid crystal composition containing the same as effective component, and liquid crystal element using the same | SUMITOMO CHEMICAL CO (JP) | 1994-09-28 | — | — | EP | disclosed |
| EP-0524409-A1 | Thermosetting bismaleinimide molding masses | BASF Aktiengesellschaft (DE) | 1993-01-27 | — | — | EP | disclosed |
| US-5143969-A | Composites with reinforcing fibers | BASF AKTIENGESELLSCHAFT (DE) | 1992-09-01 | — | — | US | disclosed |
| EP-0395390-A1 | Optically active biphenyl derivative, process for preparation thereof, liquid crystal composition containing the same as effective component, and liquid crystal element using the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-10-31 | — | — | EP | disclosed |
| US-4670882-A | Dyestuff laser | BAYER AKTIENGESELLSCHAFT (DE) | 1987-06-02 | — | — | US | disclosed |
| US-4274062-A | Dyestuff laser | BAYER AKTIENGESELLSCHAFT (DE) | 1981-06-16 | — | — | US | disclosed |
| US-4271395-A | Dyestuff laser | BAYER AKTIENGESELLSCHAFT (DE) | 1981-06-02 | — | — | US | disclosed |
| US-4256672-A | REACTING PHOSPHORUS OXYCHLORIDE OR PHOSPHORUS THIOCHLORIDE WITH AN AMINO-SUBSTUTUTED PHENOL COMPOUND | MITSUI TOATSU CHEMICALS, INC. (JP) | 1981-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | TPH1, HTR1D, HTR1B | ALDH1A1 91/4885HPGD 2392/4885BCL2L1 2446/4885 |
| US-20210346495-A1 | METHODS AND COMPOSITIONS COMPRISING AN NFKB INHIBITOR AND AN ADJUVANT | NFKBIA, IKBKG, NFKB2 | ALDH1A1 4681/4885HPGD 1342/4885BCL2L1 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.