Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4988396 | 0.81 | NPEPPS (0.43) | ALDH1A1KDM4EHTTMAPTHPGD | |
| SCHEMBL11111594 | 0.79 | ALOX5 (0.40) | CRBNALOX5ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL23005390 | 0.78 | MAPT (0.40) | ALDH1A1KDM4EMAPTPOLBEGLN1 | |
| SCHEMBL13817621 | 0.78 | CRBN (0.44) | CRBNALOX5ALDH1A1KDM4EHTT | |
| SCHEMBL23005388 | 0.77 | MALT1 (0.42) | SMN1; SMN2 | |
| SCHEMBL8256285 | 0.75 | ALDH1A1 (0.46) | ALDH1A1KDM4EHTTMAPTPOLB | |
| SCHEMBL16661530 | 0.73 | CHRNB2 (0.41) | ALDH1A1HTTMAPTMAPK1GAA | |
| SCHEMBL9109221 | 0.70 | KDM4E (0.49) | CRBNALDH1A1KDM4EHTTMAPT | |
| SCHEMBL9109233 | 0.70 | KDM4E (0.49) | CRBNALDH1A1KDM4EHTTMAPT | |
| SCHEMBL9050406 | 0.69 | ALKBH2 (0.40) | CRBNALDH1A1KDM4EPOLBALKBH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057686-A | Preparation method of bromo-pyrazole carboxylic ester compound | 沈阳中化农药化工研发有限公司 | 2022-02-18 | — | — | CN | disclosed |
| EP-1417175-B1 | SUBSTITUTED DIHYDRO 3-HALO-1H-PYRAZOLE-5-CARBOXYLATES, THEIR PREPARATION AND USE | DU PONT (US) | 2013-07-24 | — | — | EP | disclosed |
| US-7402676-B2 | Substituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-07-22 | — | — | US | disclosed |
| US-20070203342-A1 | Subtituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use | FMC CORPORATION | 2007-08-30 | — | — | US | disclosed |
| US-7227025-B2 | Substituted dihydro 3-halo-1H-pyrazole-T-carboxylates, their preparation and use | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| CN-1307161-C | Substituted dihydro-3-halo-1H-pyrazole-5-carboxylic acid esters, their preparation and use | DU PONT (US) | 2007-03-28 | — | — | CN | disclosed |
| US-6965032-B2 | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates and their preparation and use | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2005-11-15 | — | — | US | disclosed |
| US-20050245580-A1 | Halogenation and oxidation of a 5-carboxyl-3-oxo-1-aryl-substituted-1H-pyrazolidine | FMC CORPORATION | 2005-11-03 | — | — | US | disclosed |
| CN-1541206-A | Substituted dihydro 3-hylo-1H-pyrazoloe-5-carboxylates their prepn. and use | ��Ļ���Ű˾ | 2004-10-27 | — | — | CN | disclosed |
| US-20040198987-A1 | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use | FMC CORPORATION | 2004-10-07 | — | — | US | disclosed |
| EP-1417175-A1 | SUBSTITUTED DIHYDRO 3-HALO-1H-PYRAZOLE-5-CARBOXYLATES, THEIR PREPARATION AND USE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003016283-A1 | SUBSTITUTED DIHYDRO 3-HALO-1H-PYRAZOLE-5-CARBOXYLATES THEIR PREPARATION AND USE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198987-A1 | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use | CBR3, CBR1, CYP2F1 | CRBN 2854/4885ALOX5 1902/4885ALDH1A1 29/4885 |
| US-20070203342-A1 | Subtituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use | CBR3, CBR1, DHRS9 | CRBN 2291/4885ALOX5 2494/4885ALDH1A1 65/4885 |
| US-20050245580-A1 | Halogenation and oxidation of a 5-carboxyl-3-oxo-1-aryl-substituted-1H-pyrazolidine | CBR3, CBR1, CYP2F1 | CRBN 1069/4885ALOX5 668/4885ALDH1A1 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.