Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | CLPP | Q16740 | 7/20 | 0.45 |
| ▸ | DHFR | P00374 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982960 | 0.89 | LIMK1 (0.61) | MEN1KMT2AGAALIMK1MKNK1 | |
| SCHEMBL4992362 | 0.87 | LIMK1 (0.48) | MEN1KMT2ALIMK1SIGMAR1MKNK1 | |
| SCHEMBL4988843 | 0.87 | ALDH1A1 (0.47) | MEN1KMT2ALIMK1MKNK1CLPP | |
| SCHEMBL4986127 | 0.87 | LIMK1 (0.47) | LIMK1MKNK1CLPPKDM4EALDH1A1 | |
| SCHEMBL4986172 | 0.87 | SMN1; SMN2 (0.47) | MEN1KMT2AGAAATMLIMK1 | |
| SCHEMBL4984842 | 0.85 | MEN1 (0.48) | MEN1KMT2AATMLIMK1SIGMAR1 | |
| SCHEMBL4985989 | 0.84 | KDM4E (0.50) | GAALIMK1MKNK1CLPPDRD2 | |
| SCHEMBL4988786 | 0.84 | CLPP (0.51) | LIMK1CLPP | |
| SCHEMBL4985030 | 0.84 | SIGMAR1 (0.50) | MEN1KMT2AGAALIMK1SIGMAR1 | |
| SCHEMBL4985486 | 0.83 | DRD2 (0.43) | KMT2AGAALIMK1SIGMAR1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | MEN1 4853/4885KMT2A 4614/4885GAA 4179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.