Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687128 | 0.94 | GAA (0.46) | GAAALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL23345540 | 0.80 | GAA (0.42) | GAAALDH1A1MAPTTSHRRAB9A | |
| SCHEMBL16135283 | 0.80 | GAA (0.42) | GAAALDH1A1MAPTTSHRRAB9A | |
| SCHEMBL16135284 | 0.76 | TRPV1 (0.42) | ALDH1A1HSD17B10TSHRLMNAKDM4E | |
| SCHEMBL23345472 | 0.76 | TRPV1 (0.46) | GAAALDH1A1MAPTHSD17B10MEN1 | |
| SCHEMBL28040000 | 0.72 | GAA (0.44) | GAAALDH1A1MAPTTSHRLMNA | |
| SCHEMBL10384639 | 0.71 | MAPT (0.40) | GAAALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL27644092 | 0.69 | — | — | |
| SCHEMBL38728 | 0.67 | LMNA (0.46) | ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL302971 | 0.65 | TDP1 (0.47) | MAPTTSHRMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373661-B1 | NEW STEREOSPECIFIC METHOD FOR THE PREPARATION OF DIOXA-BICYCLOOCTANE NITRATE COMPOUNDS | LACER SA (ES) | 2013-03-20 | — | — | EP | disclosed |
| US-8106224-B2 | Stereospecific method for the preparation of dioxa-bicyclooctane nitrate compounds | LACER, S.A. (ES) | 2012-01-31 | — | — | US | disclosed |
| US-20110251409-A1 | STEREOSPECIFIC METHOD FOR THE PREPARATION OF DIOXA-BICYCLOOCTANE NITRATE COMPOUNDS | LACER, S.A. (ES) | 2011-10-13 | — | — | US | disclosed |
| EP-2149577-B1 | New stereospecific method for the preparation of dioxa-bicyclooctane compounds | LACER SA (ES) | 2011-04-27 | — | — | EP | disclosed |
| US-20100160652-A1 | STEREOSPECIFIC METHOD FOR THE PREPARATION OF DIOXA-BICYCLOOCTANE NITRATE COMPOUNDS | LACER, S.A. (ES) | 2010-06-24 | — | — | US | disclosed |
| EP-2199294-A1 | New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds | LACER, S.A. (ES) | 2010-06-23 | — | — | EP | disclosed |
| EP-2149577-A1 | New stereospecific method for the preparation of dioxa-bicyclooctane compounds | LACER, S.A. (ES) | 2010-02-03 | — | — | EP | disclosed |
| US-7635782-B1 | Stereospecific method for the preparation of dioxa-bicyclooctane compounds | LACER, S.A. (ES) | 2009-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251409-A1 | STEREOSPECIFIC METHOD FOR THE PREPARATION OF DIOXA-BICYCLOOCTANE NITRATE COMPOUNDS | TST, NOS3, NOS1 | GAA 3162/4885ALDH1A1 799/4885MAPT 4707/4885 |
| US-20100160652-A1 | STEREOSPECIFIC METHOD FOR THE PREPARATION OF DIOXA-BICYCLOOCTANE NITRATE COMPOUNDS | TST, NOS3, NOS1 | GAA 3277/4885ALDH1A1 771/4885MAPT 4723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.