Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5003111 | 0.78 | PIP4K2C (0.34) | ALDH1A1NPC1RAB9AKMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL5000186 | 0.77 | ADRA2A (0.36) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL9953712 | 0.71 | L3MBTL1 (0.50) | ALDH1A1L3MBTL1NPC1HTTRAB9A | |
| Hydrochloric Acid SCHEMBL5003511 | 0.67 | ALDH1A1 (0.35) | ALDH1A1NPC1RAB9AHRH1PKM | |
| SCHEMBL5004055 | 0.67 | HTR6 (0.38) | CHRNA7ALDH1A1L3MBTL1NPC1HTT | |
| Hydrochloric Acid SCHEMBL5003776 | 0.65 | CHRNA7 (0.34) | CHRNA7ALDH1A1L3MBTL1NPC1HTT | |
| SCHEMBL28343693 | 0.62 | L3MBTL1 (0.53) | ALDH1A1L3MBTL1HRH1MAPT | |
| SCHEMBL5004387 | 0.62 | HTR6 (0.38) | CHRNA7ALDH1A1L3MBTL1NPC1HTT | |
| SCHEMBL6378358 | 0.61 | HRH1 (0.44) | CHRNA7ALDH1A1L3MBTL1NPC1HTT | |
| SCHEMBL41191 | 0.60 | L3MBTL1 (0.59) | ALDH1A1L3MBTL1HRH1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824888-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2017-01-18 | — | — | EP | disclosed |
| US-20080269445-A1 | Monocyclopentadienyl Complexes | BASELL POLYOLEFINE GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
| EP-1824888-A1 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006063826-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269445-A1 | Monocyclopentadienyl Complexes | PCBP1, COASY, PORCN | CHRM2 3986/4885CHRM1 3194/4885CHRM3 2988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.