Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249570 | 0.94 | SIGMAR1 (0.47) | DRD2DRD4SIGMAR1CACNA1GALDH1A1 | |
| SCHEMBL4255387 | 0.91 | ALDH1A1 (0.59) | SIGMAR1CACNA1GALDH1A1LMNAMAPK1 | |
| SCHEMBL4251582 | 0.88 | CACNA1G (0.51) | DRD2DRD4SIGMAR1CACNA1GALDH1A1 | |
| SCHEMBL5009521 | 0.87 | CACNA1G (0.57) | DRD2DRD4SIGMAR1CACNA1GALDH1A1 | |
| SCHEMBL5011602 | 0.87 | CACNA1G (0.52) | DRD2DRD4CACNA1GDRD3 | |
| SCHEMBL13994809 | 0.86 | CACNA1G (0.48) | DRD2DRD4CACNA1GALDH1A1LMNA | |
| SCHEMBL4250699 | 0.86 | MAPT (0.51) | DRD2ALDH1A1HTR1AHTR7DRD3 | |
| SCHEMBL4246622 | 0.85 | DRD3 (0.47) | DRD2DRD4CACNA1GALDH1A1LMNA | |
| SCHEMBL5011444 | 0.85 | HTR6 (0.50) | DRD2DRD4CACNA1GALDH1A1LMNA | |
| SCHEMBL5009537 | 0.83 | MALT1 (0.48) | DRD2DRD4CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312253-A1 | Pharmaceutical compositions containing pyrazole derivatives for treating as serotonin antagonist | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-12-18 | — | — | US | claimed |
| US-20080312253-A1 | Pharmaceutical compositions containing pyrazole derivatives for treating as serotonin antagonist | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-12-18 | — | — | US | disclosed |
| US-20080312253-A1 | Pharmaceutical compositions containing pyrazole derivatives for treating as serotonin antagonist | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-12-18 | — | — | US | disclosed |
| US-20080312253-A1 | Pharmaceutical compositions containing pyrazole derivatives for treating as serotonin antagonist | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312253-A1 | Pharmaceutical compositions containing pyrazole derivatives for treating as serotonin antagonist | HTR3A, HTR3B, HTR3E | DRD2 54/4885DRD4 225/4885SIGMAR1 583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.