Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012929 | 0.90 | HPGD (0.40) | HTTHPGDL3MBTL1CNR1CNR2 | |
| SCHEMBL5016264 | 0.88 | HPGD (0.38) | HPGDCNR1CNR2KMT2AMEN1 | |
| SCHEMBL5011708 | 0.76 | CYP1A2 (0.45) | HTTHPGDL3MBTL1KMT2ALMNA | |
| SCHEMBL5013449 | 0.75 | KAT6A (0.39) | — | |
| SCHEMBL5011651 | 0.74 | CHRM2 (0.44) | L3MBTL1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL1086210 | 0.72 | HPGD (0.48) | HTTHPGDL3MBTL1ALDH1A1TSHR | |
| SCHEMBL5015150 | 0.71 | MAPT (0.53) | HTTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL5011747 | 0.67 | KCNK3 (0.40) | HPGDKMT2ALMNAALDH1A1 | |
| SCHEMBL5016419 | 0.67 | ALDH1A1 (0.41) | HTTL3MBTL1LMNAALDH1A1TSHR | |
| SCHEMBL5011879 | 0.67 | KMT2A (0.38) | HPGDKMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |