Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015752 | 0.83 | LMNA (0.43) | MAPTLMNAGAARAB9ARXFP1 | |
| SCHEMBL16175659 | 0.78 | MAPT (0.51) | MAPTLMNAGAARAB9AGRIN2B | |
| SCHEMBL5012836 | 0.75 | ALDH1A1 (0.49) | MAPTLMNAGAARAB9AALDH1A1 | |
| SCHEMBL5129622 | 0.73 | GRIN2B (0.55) | MAPTLMNAGAARAB9AGRIN2B | |
| SCHEMBL5014395 | 0.67 | RAB9A (0.43) | MAPTGAARAB9ATRPV1ALDH1A1 | |
| SCHEMBL5011187 | 0.67 | OTUD7B (0.42) | MAPTLMNAGAAGRIN2BALDH1A1 | |
| SCHEMBL5011711 | 0.67 | MAPT (0.46) | MAPTLMNAGAAGRIN2BTRPV1 | |
| SCHEMBL2096593 | 0.66 | KDR (0.71) | MAPTLMNAGAARAB9ATRPV1 | |
| SCHEMBL5048788 | 0.66 | MAPT (0.42) | MAPTLMNAGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL5015735 | 0.66 | SMN1; SMN2 (0.48) | MAPTLMNARAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |