Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20048840 | 0.79 | MAOA (0.41) | CYP2C9HSD17B2CYP3A4HSD17B1PTPN1 | |
| SCHEMBL547993 | 0.77 | RXRA (0.51) | SYKRXRARXRBPGRTNKS | |
| Hydrogen Sulfide SCHEMBL28009272 | 0.77 | MAOA (0.40) | PTPN1 | |
| SCHEMBL4517154 | 0.77 | CYP2C9 (0.48) | SYKRXRARXRBTNKSPARP1 | |
| SCHEMBL10802069 | 0.73 | PGR (0.61) | SYKPGRTNKSPARP1TNKS2 | |
| SCHEMBL4506291 | 0.72 | CYP2C9 (0.56) | TNKSPARP1TNKS2CYP2C9CYP3A4 | |
| SCHEMBL429422 | 0.72 | CYP2C9 (0.56) | TNKSPARP1TNKS2CYP2C9CYP3A4 | |
| SCHEMBL21770501 | 0.72 | TAAR1 (0.39) | CYP2C9HSD17B2CYP3A4HSD17B1MEN1 | |
| SCHEMBL18802754 | 0.72 | KIF11 (0.44) | TNKSPARP1TNKS2CYP2C9CYP3A4 | |
| SCHEMBL547767 | 0.72 | KIF11 (0.44) | TNKSPARP1TNKS2CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | disclosed |