Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.78 |
| ▸ | ITGA1 | P56199 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5020625 | 0.88 | HDAC1 (1.00) | HDAC1HDAC8ITGA1MAPTMEN1 | |
| SCHEMBL5020770 | 0.85 | HDAC1 (0.79) | HDAC1HDAC8 | |
| SCHEMBL5020762 | 0.82 | HDAC1 (0.76) | HDAC1HDAC8MEN1KMT2AHDAC3 | |
| SCHEMBL3267463 | 0.80 | HDAC1 (0.66) | HDAC1HDAC8ITGA1MAPTMEN1 | |
| SCHEMBL5020759 | 0.79 | HDAC1 (0.77) | HDAC1HDAC8MAPTLMNAKMT2A | |
| SCHEMBL14018772 | 0.77 | MAPT (0.63) | HDAC1HDAC8ITGA1MAPTMEN1 | |
| SCHEMBL3268660 | 0.75 | ITGA1 (0.68) | HDAC1HDAC8ITGA1MAPTMEN1 | |
| SCHEMBL4882914 | 0.74 | PGR (0.61) | HDAC1HDAC8ITGA1MAPTMEN1 | |
| SCHEMBL94831 | 0.74 | MAPT (0.63) | HDAC1HDAC8ITGA1MAPTMEN1 | |
| SCHEMBL28121241 | 0.74 | MAPT (0.63) | HDAC1HDAC8ITGA1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |