Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5543551 | 0.89 | KCNJ11 (0.49) | L3MBTL1KCNJ11KDM4EPOLBABCC9 | |
| SCHEMBL1272335 | 0.83 | PDK1 (0.53) | PDK1PDK2PDK3PDK4TYK2 | |
| SCHEMBL10897021 | 0.83 | RIPK1 (0.51) | L3MBTL1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5022148 | 0.83 | PTGS2 (0.49) | L3MBTL1PTGS2KCNJ11ABCC9ABCC8 | |
| SCHEMBL15625384 | 0.82 | PTGS2 (0.51) | L3MBTL1PDK1PDK2PDK3PDK4 | |
| SCHEMBL28154999 | 0.81 | CLCN2 (0.52) | L3MBTL1PDK1PDK2PDK3PDK4 | |
| SCHEMBL11856156 | 0.81 | KCNJ11 (0.49) | L3MBTL1PDK1PDK2PDK3PDK4 | |
| Hydrochloric Acid SCHEMBL5297660 | 0.81 | PDK1 (0.51) | PDK1PDK2PDK3PDK4TYK2 | |
| SCHEMBL10960660 | 0.81 | PTGS2 (0.44) | L3MBTL1PTGS2HPGDKCNJ11KDM4E | |
| SCHEMBL9474094 | 0.79 | KCNJ11 (0.42) | L3MBTL1HPGDKCNJ11KDM4ETRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638014-B1 | N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF ROR-GAMMA ACTIVITY AND THE TREATMENT OF DISEASES | LYCERA CORP (US) | 2017-01-04 | — | — | EP | disclosed |
| US-9512111-B2 | N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease | LYCERA CORPORATION (US) | 2016-12-06 | — | — | US | disclosed |
| US-20140088094-A1 | N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME CORP. (US) | 2014-03-27 | — | — | US | disclosed |
| WO-2012064744-A2 | TETRAHYDROQUINOLINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORϒ ACTIVITY AND THE TREATMENT OF DISEASE | LYCERA CORPORATION (US) | 2012-05-18 | — | — | WO | disclosed |
| EP-0507417-B1 | Process for the selective reduction of the 4-halogen in 2,4-dihaloanilines | DOWELANCO (US) | 1995-11-08 | — | — | EP | disclosed |
| EP-0507417-A2 | Process for the selective reduction of the 4-halogen in 2,4-dihaloanilines | DOWELANCO (US) | 1992-10-07 | — | — | EP | disclosed |
| US-5089653-A | Having amine-protecting groups, such as diacetanilide or succinimide; palladium catalyst; hydrolyzing to deprotect | DOW ELANCO (US) | 1992-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088094-A1 | N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | RORC, RORB, RORA | L3MBTL1 4153/4885PDK1 3444/4885PDK2 2844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.