Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023769 | 0.70 | KDM4E (0.43) | ALDH1A1KDM4ETSHRKMT2A | |
| SCHEMBL3859892 | 0.69 | CACNA1B (0.46) | KDM4ELMNAGAAMAPK1HTT | |
| SCHEMBL7936471 | 0.69 | HRH3 (0.47) | ALDH1A1SLC18A3KDM4EHRH3ACHE | |
| SCHEMBL5023619 | 0.68 | DRD2 (0.51) | — | |
| SCHEMBL8672692 | 0.67 | SLC18A3 (0.43) | ALDH1A1SLC18A3KDM4EPOLBLMNA | |
| Benzylic Acid SCHEMBL11259414 | 0.66 | KDM4E (0.50) | ALDH1A1SLC18A3KDM4EPOLBHRH3 | |
| SCHEMBL5194252 | 0.65 | KEAP1 (0.42) | POLBTSHRSIGMAR1 | |
| SCHEMBL22848097 | 0.65 | L3MBTL3 (0.70) | ALDH1A1SLC18A3KDM4EHRH3GAA | |
| SCHEMBL22848095 | 0.65 | L3MBTL3 (0.70) | ALDH1A1SLC18A3KDM4EHRH3GAA | |
| SCHEMBL8584491 | 0.65 | L3MBTL3 (0.70) | ALDH1A1SLC18A3KDM4EHRH3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | disclosed |