Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 6/20 | 0.54 |
| ▸ | KDM2A | Q9Y2K7 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | KDM5C | P41229 | 4/20 | 0.54 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.54 |
| ▸ | KDM6B | O15054 | 2/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ECE1 | P42892 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810784 | 0.87 | PHF8 (0.60) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL15080736 | 0.87 | CASP2 (0.52) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL17278230 | 0.87 | EPHX2 (0.54) | KDM4EALDH1A1LMNAKMT2AEPHX2 | |
| SCHEMBL16281002 | 0.86 | ALDH1A1 (0.45) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL14002750 | 0.85 | ALDH1A1 (0.48) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL12251401 | 0.84 | PHF8 (0.44) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL19115845 | 0.84 | ALDH1A1 (0.46) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL16687527 | 0.83 | ECE1 (0.41) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL1387345 | 0.83 | NAAA (0.57) | ALDH1A1KMT2ANAAA | |
| SCHEMBL13839061 | 0.83 | FAAH (0.50) | ALDH1A1KMT2ANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054981-B1 | PROTECTING GROUP COMPRISING A PURIFICATION TAG | ASCENDIS PHARMA AS (DK) | 2020-07-29 | — | — | EP | disclosed |
| US-9321781-B2 | Topoisomerase inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-04-26 | — | — | US | disclosed |
| EP-1984726-B1 | METHODS, MIXTURES, KITS AND COMPOSITIONS PERTAINING TO ANALYTE DETERMINATION | DH TECHNOLOGIES DEV PTE LTD (SG) | 2015-06-17 | — | — | EP | disclosed |
| US-8975404-B2 | Labeling reagents for analyte determination and methods and compounds used in making the same | DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (SG) | 2015-03-10 | — | — | US | disclosed |
| US-20120237531-A1 | TOPOISOMERASE INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2012-09-20 | — | — | US | disclosed |
| WO-2010127363-A1 | TOPOSIOMERASE INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2010-11-04 | — | — | WO | disclosed |
| EP-1984726-A2 | METHODS, MIXTURES, KITS AND COMPOSITIONS PERTAINING TO ANALYTE DETERMINATION | Applera Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| US-20070218560-A1 | Methods, Mixtures, Kits and Compositions Pertaining to Analyte Determination | APPLERA CORPORATION. (US) | 2007-09-20 | — | — | US | disclosed |
| WO-2007087534-A2 | METHODS, MIXTURES, KITS AND COMPOSITIONS PERTAINING TO ANALYTE DETERMINATION | APPLERA CORPORATION (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070218560-A1 | Methods, Mixtures, Kits and Compositions Pertaining to Analyte Determination | SRMS, CA13, KLK3 | PHF8 3012/4885KDM2A 3327/4885KDM4E 3535/4885 |
| US-20120237531-A1 | TOPOISOMERASE INHIBITORS | TOP1, TOP2A, TOP2B | PHF8 1259/4885KDM2A 786/4885KDM4E 1279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.