Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190178 | 0.88 | POLB (0.52) | POLBATML3MBTL1LMNAHTT | |
| SCHEMBL5039076 | 0.82 | CYP3A4 (0.39) | GAATP53MEN1KMT2ASRC | |
| SCHEMBL5039110 | 0.79 | CYP3A4 (0.42) | POLBL3MBTL1GAAMEN1KMT2A | |
| SCHEMBL5032620 | 0.77 | HPGD (0.39) | POLBLMNAHTTGAATP53 | |
| SCHEMBL5041330 | 0.76 | CYP3A4 (0.44) | POLBLMNAMEN1KMT2AMAPT | |
| SCHEMBL5036060 | 0.76 | CYP3A4 (0.43) | L3MBTL1KMT2AMAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL5039137 | 0.76 | POLB (0.40) | POLBHTTMEN1KMT2AMAPT | |
| SCHEMBL5032567 | 0.76 | CYP3A4 (0.49) | L3MBTL1GAAKMT2AMAPTCYP3A4 | |
| SCHEMBL5035128 | 0.75 | C5AR1 (0.41) | GAATP53MEN1KMT2ASRC | |
| SCHEMBL5035268 | 0.74 | LIPE (0.47) | POLBGAAKMT2ACYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | claimed |