SCHEMBL5039508

SCHEMBL5039508

CCCCCCCCCCCCNC(=O)c1ccc(-c2ccc(CC(NC(=O)C(=O)O)c3cccc(OC(F)(F)F)c3)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 1/20 0.44
ROCK1 Q13464 1/20 0.44
GCGR P47871 3/20 0.43
GPR139 Q6DWJ6 1/20 0.43
MLYCD O95822 1/20 0.43
NAMPT P43490 1/20 0.43
EPHX2 P34913 1/20 0.42
PPARG P37231 1/20 0.42
PPARA Q07869 1/20 0.42
MAPK14 Q16539 1/20 0.42
NAAA Q02083 1/20 0.42
TRPV1 Q8NER1 1/20 0.42
MME P08473 1/20 0.42
PTGS2 P35354 1/20 0.41
KIFC1 Q9BW19 1/20 0.41
DRD2 P14416 2/20 0.41
DRD4 P21917 2/20 0.41
DRD3 P35462 2/20 0.41
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5044617 0.86 ROCK2 (0.47) ROCK2ROCK1GCGRGPR139MLYCD
SCHEMBL1853396 0.85 MLYCD (0.47) GCGRGPR139MLYCDEPHX2PPARG
SCHEMBL6022121 0.85 GPR139 (0.43) GCGRGPR139MLYCDNAMPTMAPK14
SCHEMBL5039754 0.84 PPARG (0.47) MLYCDEPHX2PPARGPPARANAAA
SCHEMBL5047162 0.82 HDAC1 (0.44) MLYCDEPHX2PPARGPPARANAAA
SCHEMBL5039660 0.82 HDAC1 (0.44) MLYCDEPHX2PPARGPPARANAAA
SCHEMBL1852984 0.80 MLYCD (0.51) GCGRMLYCDNAMPTEPHX2PPARG
SCHEMBL5048720 0.78 PPARG (0.50) ROCK2EPHX2PPARGPPARAMAPK14
SCHEMBL1855346 0.78 ROCK2 (0.50) ROCK2ROCK1GCGRMLYCDNAMPT
SCHEMBL1853969 0.78 MLYCD (0.44) GCGRMLYCDEPHX2PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1732534-B1 USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS SERONO LAB (CH) 2008-07-23 EP disclosed