SCHEMBL1853396

SCHEMBL1853396

CCCCCCCCCCCCNC(=O)c1ccc(CC(NC(=O)C(=O)O)c2cccc(C(F)(F)F)c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.47
ALDH1A1 P00352 1/20 0.47
POLB P06746 1/20 0.47
GCGR P47871 7/20 0.46
NAAA Q02083 1/20 0.46
HDAC8 Q9BY41 1/20 0.44
SLC6A9 P48067 1/20 0.44
LMNA P02545 1/20 0.44
GIPR P48546 1/20 0.44
KCNH2 Q12809 1/20 0.44
MRGPRX4 Q96LA9 1/20 0.43
TP53BP1 Q12888 1/20 0.43
PLK1 P53350 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
PPARG P37231 2/20 0.42
PPARA Q07869 2/20 0.42
PPARD Q03181 1/20 0.42
GPR139 Q6DWJ6 1/20 0.42
EPHX2 P34913 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1853969 0.90 MLYCD (0.44) MLYCDALDH1A1POLBGCGRNAAA
SCHEMBL1852984 0.90 MLYCD (0.51) MLYCDALDH1A1GCGRNAAAGIPR
SCHEMBL6022126 0.88 ALDH1A1 (0.46) MLYCDALDH1A1POLBGCGRNAAA
SCHEMBL5039508 0.85 ROCK2 (0.44) MLYCDGCGRNAAAPPARGPPARA
SCHEMBL5039660 0.85 HDAC1 (0.44) MLYCDALDH1A1POLBNAAAMRGPRX4
SCHEMBL5047162 0.85 HDAC1 (0.44) MLYCDALDH1A1POLBNAAAMRGPRX4
SCHEMBL1853036 0.78 TMEM97 (0.46) MLYCDALDH1A1POLBGCGRNAAA
SCHEMBL1852697 0.76 MLYCD (0.58) MLYCDALDH1A1POLBNAAALMNA
SCHEMBL4978882 0.76 PLK1 (0.47) HDAC8PLK1PPARA
SCHEMBL5048862 0.76 ALDH1A1 (0.56) MLYCDALDH1A1POLBNAAALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1470102-B1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) MERCK SERONO SA (CH) 2011-05-25 EP disclosed
EP-1470102-A1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) Applied Research Systems ARS Holding N.V. (AN) 2004-10-27 EP disclosed
WO-2003064376-A1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2003-08-07 WO disclosed