Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 known ✓ | P30411 | 7/20 | 0.71 |
| ▸ | RARB | P10826 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11204396 | 0.80 | RARB (0.54) | BDKRB2RARBALDH1A1MEN1RARA | |
| Bromide SCHEMBL30466581 | 0.80 | BDKRB2 (0.64) | BDKRB2ALDH1A1MAPT | |
| SCHEMBL9700188 | 0.79 | RARB (0.53) | BDKRB2RARBALDH1A1MEN1RARA | |
| Bromide SCHEMBL11601966 | 0.78 | FOLH1 (0.50) | BDKRB2FOLH1TP53 | |
| Hydrochloric Acid SCHEMBL465040 | 0.78 | BDKRB2 (0.71) | BDKRB2MEN1KMT2ATP53 | |
| Terephthalic Acid SCHEMBL28198649 | 0.77 | RARB (0.53) | RARBALDH1A1MEN1RARAMAPT | |
| Hydrochloric Acid SCHEMBL10577821 | 0.77 | BDKRB2 (0.75) | BDKRB2 | |
| Terephthalic Acid SCHEMBL29199831 | 0.77 | RARB (0.53) | RARBALDH1A1MEN1RARAMAPT | |
| Acetic Acid SCHEMBL16209117 | 0.77 | BDKRB2 (0.54) | BDKRB2 | |
| SCHEMBL8841547 | 0.76 | RARB (0.62) | BDKRB2RARBALDH1A1MEN1RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799846-A4 | METHODS FOR ISOLATING NUCLEIC ACIDS FROM BIOLOGICAL AND CELLULAR MATERIALS | NEXGEN DIAGNOSTICS LLC (US) | 2008-01-16 | — | — | EP | disclosed |
| CN-101076603-A | Simplified methods for isolating nucleic acids from cellular materials | LUMIGEN INC (US) | 2007-11-21 | — | — | CN | disclosed |
| EP-1799846-A2 | METHODS FOR ISOLATING NUCLEIC ACIDS FROM BIOLOGICAL AND CELLULAR MATERIALS | LUMIGEN, INC. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006036243-A2 | METHODS FOR ISOLATING NUCLEIC ACIDS FROM BIOLOGICAL AND CELLULAR MATERIALS | LUMIGEN, INC. (US) | 2006-04-06 | — | — | WO | disclosed |
| US-20050136477-A1 | Methods for isolating nucleic acids from biological and cellular materials | NEXGEN DIAGNOSTICS LLC | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050136477-A1 | Methods for isolating nucleic acids from biological and cellular materials | NSUN2, DNA2, POLB | BDKRB2 4440/4885RARB 1743/4885ALDH1A1 4724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.