Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12411449 | 0.82 | NPC1 (0.33) | NPC1LMNAMAPTTSHRL3MBTL1 | |
| SCHEMBL13400767 | 0.77 | NPC1 (0.31) | NPC1LMNAMAPTRAB9AHPGD | |
| SCHEMBL661893 | 0.76 | NPC1 (0.32) | NPC1MAPTRAB9AHPGDSMN1; SMN2 | |
| SCHEMBL15601113 | 0.75 | RAB9A (0.53) | NPC1LMNAMAPTTSHRRAB9A | |
| SCHEMBL31201034 | 0.75 | TSHR (0.38) | TSHRDHFRPKMTDP1 | |
| SCHEMBL15275931 | 0.74 | NPC1 (0.50) | NPC1LMNAMAPTTSHRL3MBTL1 | |
| SCHEMBL5040917 | 0.73 | TSHR (0.49) | NPC1TSHRRAB9ADHFRPKM | |
| SCHEMBL3711651 | 0.72 | TDP1 (0.50) | NPC1LMNAMAPTTSHRRAB9A | |
| SCHEMBL4299406 | 0.71 | LMNA (0.38) | NPC1LMNATSHRRAB9ADHFR | |
| SCHEMBL15275929 | 0.69 | KCNA3 (0.54) | NPC1LMNATSHRL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166351-A1 | METHOD FOR PREPARING 5-[2-(METHYLTHIO)ETHOXY]PYRIMIDINE-2-AMINE | KOWA COMPANY, LTD. (JP) | 2011-07-07 | — | — | US | claimed |
| EP-2332923-A1 | 5-Ý2-(METHYLTHIO)ETHOXY¨PYRIMIDINE-2-AMINE MANUFACTURING METHOD | Kowa Company, Ltd. (JP) | 2011-06-15 | — | — | EP | claimed |
| US-9315493-B2 | Phenylpyridine derivative and drug containing same | KOWA COMPANY, LTD. (JP) | 2016-04-19 | — | — | US | disclosed |
| EP-2149563-B9 | NOVEL PYRIMIDINE COMPOUND HAVING DIBENZYLAMINE STRUCTURE, AND MEDICINE COMPRISING THE COMPOUND | KOWA CO (JP) | 2015-04-22 | — | — | EP | disclosed |
| EP-2149563-B1 | NOVEL PYRIMIDINE COMPOUND HAVING DIBENZYLAMINE STRUCTURE, AND MEDICINE COMPRISING THE COMPOUND | KOWA CO (JP) | 2015-01-07 | — | — | EP | disclosed |
| EP-2484675-B1 | NOVEL PHENYLPYRIDINE DERIVATIVE AND MEDICINAL AGENT COMPRISING SAME | KOWA CO (JP) | 2014-11-05 | — | — | EP | disclosed |
| US-8778954-B2 | Phenylpyridine derivative and medicinal agent comprising same | KOWA COMPANY, LTD. (JP) | 2014-07-15 | — | — | US | disclosed |
| US-8664226-B2 | Compound having 3-heteroarylpyrimidin-4-(3H)-one structure and pharmaceutical preparation containing same | KOWA COMPANY, LTD. (JP) | 2014-03-04 | — | — | US | disclosed |
| EP-2687523-A1 | NOVEL PHENYLPYRIDINE DERIVATIVE AND DRUG CONTAINING SAME | Kowa Company Ltd. (JP) | 2014-01-22 | — | — | EP | disclosed |
| US-20140011823-A1 | NOVEL PHENYLPYRIDINE DERIVATIVE AND DRUG CONTAINING SAME | KOWA COMPANY, LTD. (JP) | 2014-01-09 | — | — | US | disclosed |
| WO-2013137371-A1 | NOVEL PYRIMIDINE COMPOUND AND MEDICINE COMPRISING SAME | 興和株式会社 (JP) | 2013-09-19 | — | — | WO | disclosed |
| US-7750019-B2 | Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same | KOWA COMPANY, LTD. (JP) | 2010-07-06 | — | — | US | disclosed |
| WO-2010029756-A1 | 5-[2-(METHYLTHIO)ETHOXY]PYRIMIDINE-2-AMINE MANUFACTURING METHOD | 興和株式会社 (JP) | 2010-03-18 | — | — | WO | disclosed |
| US-7659271-B2 | Pyrimidine compound having dibenzylamine structure and medicament comprising the same | KOWA COMPANY, LTD. (JP) | 2010-02-09 | — | — | US | disclosed |
| EP-2149563-A1 | NOVEL PYRIMIDINE COMPOUND HAVING DIBENZYLAMINE STRUCTURE, AND MEDICINE COMPRISING THE COMPOUND | Kowa Company. Ltd. (JP) | 2010-02-03 | — | — | EP | disclosed |
| EP-2138489-A1 | NOVEL PYRIMIDINE COMPOUND HAVING BENZYL(HETEROCYCLICMETHYL)AMINE STRUCTURE AND PHARMACEUTICAL PRODUCT CONTAINING THE SAME | Kowa Company. Ltd. (JP) | 2009-12-30 | — | — | EP | disclosed |
| EP-2055703-A1 | NOVEL PYRIMIDINE COMPOUND HAVING BENZYL(PYRIDYLMETHYL)AMINE STRUCTURE AND PHARMACEUTICAL COMPRISING THE COMPOUND | Kowa Company. Ltd. (JP) | 2009-05-06 | — | — | EP | disclosed |
| US-20090082352-A1 | N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine; inhibitory activity on cholesterol ester transfer protein (CETP) | KOWA COMPANY, LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| US-20090062306-A1 | NOVEL PYRIMIDINE COMPOUNDS HAVING BENZYL (HETEROCYCLIC METHYL) AMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME | KOWA COMPANY, LTD. (JP) | 2009-03-05 | — | — | US | disclosed |
| US-20090054474-A1 | Novel pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same | KOWA COMPANY, LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054474-A1 | Novel pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same | CETP, TYMP, MTTP | NPC1 269/4885LMNA 3871/4885MAPT 4462/4885 |
| US-20090082352-A1 | N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine; inhibitory activity on cholesterol ester transfer protein (CETP) | CETP, NPC1L1, MTTP | NPC1 4/4885LMNA 2286/4885MAPT 3761/4885 |
| US-20110166351-A1 | METHOD FOR PREPARING 5-[2-(METHYLTHIO)ETHOXY]PYRIMIDINE-2-AMINE | TPMT, AASDHPPT, MTAP | NPC1 4381/4885LMNA 4419/4885MAPT 1486/4885 |
| US-20090062306-A1 | NOVEL PYRIMIDINE COMPOUNDS HAVING BENZYL (HETEROCYCLIC METHYL) AMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME | CETP, MTTP, NPC1L1 | NPC1 4/4885LMNA 3334/4885MAPT 3936/4885 |
| US-20140011823-A1 | NOVEL PHENYLPYRIDINE DERIVATIVE AND DRUG CONTAINING SAME | AGTR2, AGTR1, PPARD | NPC1 2133/4885LMNA 4074/4885MAPT 3981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.