Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Methylene Chloride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL1094696 | 0.96 | — | — | |
| Methylene Chloride SCHEMBL7525558 | 0.88 | — | — | |
| Methylene Chloride SCHEMBL1595622 | 0.88 | — | — | |
| Acetone SCHEMBL9472113 | 0.86 | LMNA (0.40) | — | |
| Formic Acid SCHEMBL28224036 | 0.84 | — | — | |
| Acetonitrile SCHEMBL7938685 | 0.83 | — | — | |
| Methylene Chloride SCHEMBL10795300 | 0.83 | KDM4E (0.30) | — | |
| Alcohol SCHEMBL11143126 | 0.81 | — | — | |
| Acetone SCHEMBL8359214 | 0.81 | LMNA (0.43) | — | |
| Ethyl Chloride SCHEMBL27286428 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113391020-A | Thin-layer identification method for sinopodophyllum hexandrum | 中国科学院西北高原生物研究所 | 2021-09-14 | — | — | CN | claimed |
| CN-103058859-B | Simultaneous preparation and detection method of gallic acid and gallicin in toona sinensis leaves | UNIV JIANGSU | 2014-12-24 | — | — | CN | claimed |
| CN-103058859-A | Simultaneous preparation and detection method of gallic acid and gallicin in toona sinensis leaves | UNIV JIANGSU | 2013-04-24 | — | — | CN | claimed |
| CN-117310070-A | Thin layer identification method for medulla tetrapanacis and preparation thereof | 江阴天江药业有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-115998754-A | Application of saponin derivative in preparing medicament for treating and preventing ulcerative colitis, preparation method and application | 东北大学 | 2023-04-25 | — | — | CN | disclosed |
| CN-113391020-A | Thin-layer identification method for sinopodophyllum hexandrum | 中国科学院西北高原生物研究所 | 2021-09-14 | — | — | CN | disclosed |
| CN-113391020-A | Thin-layer identification method for sinopodophyllum hexandrum | 中国科学院西北高原生物研究所 | 2021-09-14 | — | — | CN | disclosed |
| CN-103058859-B | Simultaneous preparation and detection method of gallic acid and gallicin in toona sinensis leaves | UNIV JIANGSU | 2014-12-24 | — | — | CN | disclosed |
| CN-103058859-A | Simultaneous preparation and detection method of gallic acid and gallicin in toona sinensis leaves | UNIV JIANGSU | 2013-04-24 | — | — | CN | disclosed |
| US-7407946-B2 | Quinazoline compounds | ASTRAZENECA AB (SE) | 2008-08-05 | — | — | US | disclosed |
| US-20060058523-A1 | Quinazoline compounds | ASTRAZENECA AB (SE) | 2006-03-16 | — | — | US | disclosed |
| EP-1575946-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058752-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |