Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.60 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.60 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.46 |
| ▸ | HTR3B | O95264 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.45 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4433916 | 0.98 | CHRNA7 (0.59) | CHRNA7CHRNA10CHRNA9ADRB2NCF1 | |
| SCHEMBL14654390 | 0.84 | CHRNA7 (0.63) | CHRNA7CHRNA10CHRNA9LTA4H | |
| SCHEMBL29639915 | 0.77 | KCNH2 (0.43) | CHRNA7CHRNA10CHRNA9ADRB2NCF1 | |
| SCHEMBL8226116 | 0.77 | KCNH2 (0.43) | CHRNA7CHRNA10CHRNA9ADRB2NCF1 | |
| SCHEMBL27007682 | 0.77 | ADRB1 (0.52) | ADRB2NCF1PLD1ADRB1HTR3E | |
| SCHEMBL15245011 | 0.75 | ADRB1 (0.68) | ADRB2NCF1PLD1ADRB1HTR3E | |
| SCHEMBL722557 | 0.75 | LTA4H (0.64) | CHRNA7CHRNA10CHRNA9LTA4H | |
| Piperazine SCHEMBL3360835 | 0.75 | HPGDS (0.59) | CHRNA7CHRNA10CHRNA9USP9XLTA4H | |
| SCHEMBL29639951 | 0.74 | HTR7 (0.44) | ADRB2NCF1HTR3ADYRK1A | |
| SCHEMBL1200127 | 0.73 | PLD1 (0.56) | ADRB2NCF1PLD1CDC7PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-B1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |
| EP-1007524-B1 | INDOLE DERIVATIVES AS 5-HT1B AND 5-HT1D AGONISTS | PF MEDICAMENT (FR) | 2003-11-12 | — | — | EP | disclosed |
| US-6589953-B2 | Treatment of anxiety, depression, aggressiveness, panic attacks, obsessive-compulsive disorders, schizophrenia, suicidal tendency, neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease | PIERRE FABRE MEDICAMENT (FR) | 2003-07-08 | — | — | US | disclosed |
| US-20020061891-A1 | Indole derivatives as 5-HT1B and 5-HT1D agonists | PEREZ MICHEL (FR) | 2002-05-23 | — | — | US | disclosed |
| US-6277853-B1 | FOR TREATMENT OF NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS, MIGRAINES, ALCOHOLISM | PIERRE FABRE MEDICAMENT (FR) | 2001-08-21 | — | — | US | disclosed |
| EP-1007524-A1 | INDOLE DERIVATIVES AS 5-HT1B AND 5-HT1D AGONISTS | PIERRE FABRE MEDICAMENT (FR) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010344-A1 | INDOLE DERIVATIVES AS 5-HT1B AND 5-HT1D AGONISTS | PIERRE FABRE MEDICAMENT (FR) | 1999-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020061891-A1 | Indole derivatives as 5-HT1B and 5-HT1D agonists | HTR1B, HTR1A, HTR1D | CHRNA7 175/4885CHRNA10 209/4885CHRNA9 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.