Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854176 | 0.84 | NAAA (0.40) | DRD2DRD4DRD3NAAAASAH1 | |
| SCHEMBL5043673 | 0.83 | ALDH1A1 (0.50) | NAAACYP1A2CYP2D6CYP2C19MLYCD | |
| SCHEMBL5045263 | 0.80 | MAPK14 (0.48) | NAAACYP1A2CYP2D6CYP2C19MLYCD | |
| SCHEMBL5048336 | 0.80 | NAAA (0.41) | DRD2DRD4DRD3NAAAASAH1 | |
| SCHEMBL6022200 | 0.77 | DRD2 (0.49) | DRD2DRD4DRD3NAAAASAH1 | |
| SCHEMBL5039489 | 0.77 | MLYCD (0.50) | NAAAMLYCDSMN1; SMN2BCHEACHE | |
| SCHEMBL5047987 | 0.76 | PTGS2 (0.41) | DRD2DRD4DRD3NAAAASAH1 | |
| SCHEMBL4325004 | 0.75 | AKR1C4 (0.40) | LMNAHPGD | |
| SCHEMBL1853343 | 0.75 | TMEM97 (0.50) | DRD2DRD4DRD3NAAAMLYCD | |
| SCHEMBL1855176 | 0.73 | NAAA (0.68) | NAAAMLYCDSMN1; SMN2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | disclosed |