Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL5050696 | 1.00 | PTGS1 (0.31) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| Lithium Ion SCHEMBL11107854 | 0.98 | PTGS1 (0.30) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| SCHEMBL4162092 | 0.98 | CA4 (0.33) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| SCHEMBL676893 | 0.98 | CA4 (0.33) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| Potassium Ion SCHEMBL514904 | 0.88 | APP (0.35) | EPHX2 | |
| Potassium Ion SCHEMBL514903 | 0.88 | APP (0.35) | EPHX2 | |
| Potassium Ion SCHEMBL11801337 | 0.86 | EPHX2 (0.41) | EPHX2 | |
| SCHEMBL2511007 | 0.86 | APP (0.34) | CA4EPHX2 | |
| Lithium Ion SCHEMBL28840842 | 0.86 | APP (0.34) | EPHX2 | |
| SCHEMBL4251605 | 0.86 | APP (0.34) | CA4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4319014-A | UNDATURATED CARBOXYLIC ACID COPOLYMER WITH UNDATURATED SULFONATE COMONOMER MODIFIED BY A MERCAPTAN | UNIROYAL, INC. (US) | 1982-03-09 | — | — | US | claimed |
| US-20080281014-A1 | Nanosubstance-Containing Composition, Process for Producing the Same, and Composite Made With the Same | MITSUBISHI RAYON CO., LTD. (JP) | 2008-11-13 | — | — | US | disclosed |