Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.51 |
| ▸ | CES1 | P23141 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3730123 | 0.83 | CES2 (0.54) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL5054802 | 0.81 | ALKBH5 (0.47) | CES2CES1KMT2AMEN1L3MBTL1 | |
| SCHEMBL5316600 | 0.80 | LMNA (0.49) | CES2CES1PARP1CHRNB2SLC6A2 | |
| SCHEMBL5052427 | 0.80 | MMP2 (0.47) | CES2CES1SLC6A2SLC6A3KMT2A | |
| SCHEMBL3362925 | 0.79 | CES2 (0.61) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL5060468 | 0.79 | CES2 (0.50) | CES2CES1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL5316414 | 0.77 | CES2 (0.50) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL312334 | 0.76 | CES2 (0.57) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL28075891 | 0.76 | CES2 (0.57) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL11088672 | 0.76 | TP53 (0.58) | CES2CES1SLC6A2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | 7TM PHARMA A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | 7TM PHARMA A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | 7TM PHARMA A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| CN-1980908-A | Substituted thiazoleacetic as CRTH2 ligands | 7TM PHARMA AS (DK) | 2007-06-13 | — | — | CN | disclosed |
| WO-2007062797-A1 | AMINO-SUBSTITUTED AZO-HETEROCYCLIC COMPOUNDS FOR TREATING INFLAMMATORY CONDITIONS | 7TM PHARMA A/S (DK) | 2007-06-07 | — | — | WO | disclosed |
| WO-2007062797-A1 | AMINO-SUBSTITUTED AZO-HETEROCYCLIC COMPOUNDS FOR TREATING INFLAMMATORY CONDITIONS | 7TM PHARMA A/S (DK) | 2007-06-07 | — | — | WO | disclosed |
| EP-1758874-A1 | SUBSTITUTED THIAZOLEACETIC ACIDS AS CRTH2 LIGANDS | 7TM Pharma A/S (DK) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005116001-A1 | SUBSTITUTED THIAZOLEACETIC AS CRTH2 LIGANDS | 7TM PHARMA A/S (DK) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | HRH1, HRH2, HRH3 | CES2 1971/4885CES1 1572/4885PARP1 4569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.