Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL16910001 | 0.92 | TP53 (0.39) | TP53MEN1KMT2A | |
| SCHEMBL28150851 | 0.82 | TP53 (0.30) | TP53 | |
| Methyl Alcohol SCHEMBL2652388 | 0.82 | MEN1 (0.38) | MEN1KMT2A | |
| SCHEMBL7097725 | 0.82 | — | — | |
| SCHEMBL5544690 | 0.82 | MEN1 (0.42) | MEN1KMT2A | |
| SCHEMBL1746 | 0.82 | — | — | |
| Trifluoromethanesulfonic Acid SCHEMBL628113 | 0.80 | EPHX1 (0.31) | — | |
| Bicarbonate SCHEMBL27506741 | 0.80 | FFAR3 (0.35) | TP53MEN1KMT2AHDAC1HDAC8 | |
| SCHEMBL28327980 | 0.80 | MEN1 (0.33) | MEN1KMT2A | |
| Isopropyl Alcohol SCHEMBL28105402 | 0.79 | ALDH1A1 (0.40) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630848-B1 | PROCESS FOR GALNAC OLIGONUCLEOTIDE CONJUGATES | HOFFMANN LA ROCHE (CH) | 2023-10-04 | — | — | EP | disclosed |
| CN-110621700-B | Method for GalNAc oligonucleotide conjugates | 豪夫迈·罗氏有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-107709342-B | Process for preparing acetylgalactosamine acid derivatives | 豪夫迈·罗氏有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-108738321-B | GalNAc cluster phosphoramidites | 豪夫迈·罗氏有限公司 | 2021-06-11 | — | — | CN | disclosed |
| US-11021503-B2 | Process for GalNAc oligonucleotide conjugates | HOFFMANN-LA ROCHE INC. (US) | 2021-06-01 | — | — | US | disclosed |
| CN-108738321-A9 | GalNAc cluster phosphoramidites | 豪夫迈·罗氏有限公司 | 2021-01-29 | — | — | CN | disclosed |
| EP-3377510-B1 | GALNAC CLUSTER PHOSPHORAMIDITE | HOFFMANN LA ROCHE (CH) | 2020-12-02 | — | — | EP | disclosed |
| US-10590156-B2 | Galnac cluster phosphoramidite | HOFFMANN-LA ROCHE INC. (US) | 2020-03-17 | — | — | US | disclosed |
| US-20200079807-A1 | PROCESS FOR GALNAC OLIGONUCLEOTIDE CONJUGATES | HOFFMANN-LA ROCHE INC. (US) | 2020-03-12 | — | — | US | disclosed |
| CN-110621700-A | Methods for GalNAc oligonucleotide conjugates | 豪夫迈·罗氏有限公司 | 2019-12-27 | — | — | CN | disclosed |
| CN-106715435-B | Pyrrolopyrimidine derivatives as NR2B nmda receptor antagonist | 卢郡控股(开曼)有限公司 | 2019-10-01 | — | — | CN | disclosed |
| US-20180258122-A1 | GALNAC CLUSTER PHOSPHORAMIDITE | HOFFMANN-LA ROCHE INC. (US) | 2018-09-13 | — | — | US | disclosed |
| CN-101346379-A | Per-cyclic tricyclic compounds useful as antibacterial agents | GLAXO GROUP LTD (GB) | 2009-01-14 | — | — | CN | disclosed |
| US-20080070795-A1 | LINKER COMPOUND, PROBE, AND PROBE-IMMOBILIZED CARRIER | KYOTO UNIVERSITY (JP) | 2008-03-20 | — | — | US | disclosed |
| EP-1857461-A1 | LINKER COMPOUND, PROBE, AND CARRIER HAVING PROBE IMMOBILIZED THEREON | Kyoto University (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079807-A1 | PROCESS FOR GALNAC OLIGONUCLEOTIDE CONJUGATES | CSGALNACT1, ALG1, ALG8 | TP53 2872/4885GRIA1 527/4885MEN1 3053/4885 |
| US-20180258122-A1 | GALNAC CLUSTER PHOSPHORAMIDITE | B4GALT1, FUT5, FUT6 | TP53 1792/4885GRIA1 249/4885MEN1 699/4885 |
| US-11021503-B2 | Process for GalNAc oligonucleotide conjugates | CSGALNACT1, ALG1, ALG8 | TP53 2872/4885GRIA1 527/4885MEN1 3053/4885 |
| US-20080070795-A1 | LINKER COMPOUND, PROBE, AND PROBE-IMMOBILIZED CARRIER | SLC2A1, GPI, SLC2A4 | TP53 4475/4885GRIA1 491/4885MEN1 1803/4885 |
| US-10590156-B2 | Galnac cluster phosphoramidite | B4GALT1, FUT5, FUT6 | TP53 1792/4885GRIA1 249/4885MEN1 699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.