Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.40 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.40 |
| ▸ | ATIC | P31939 | 3/20 | 0.40 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.39 |
| ▸ | GART | P22102 | 7/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3195061 | 0.90 | MTHFD1 (0.44) | DHFRMTHFD2MTHFD1ATICSOST | |
| Leucovorin SCHEMBL1259919 | 0.87 | DHFR (0.71) | DHFRMTHFD2MTHFD1ATICSOST | |
| SCHEMBL8406397 | 0.85 | FPGS (0.41) | DHFRMTHFD2MTHFD1ATICSOST | |
| SCHEMBL14843581 | 0.84 | DHFR (0.46) | DHFRMTHFD2MTHFD1ATICSOST | |
| SCHEMBL7757766 | 0.78 | DHFR (0.31) | DHFR | |
| SCHEMBL2906514 | 0.76 | TYMS (0.62) | DHFRATICGART | |
| SCHEMBL4616964 | 0.74 | MTHFD1 (0.47) | DHFRMTHFD2MTHFD1ATICSOST | |
| SCHEMBL17097094 | 0.67 | MTHFD1 (0.63) | DHFRMTHFD2MTHFD1ATICSOST | |
| SCHEMBL2166341 | 0.67 | MTHFD1 (0.63) | DHFRMTHFD2MTHFD1ATICSOST | |
| SCHEMBL15531651 | 0.65 | AKR1B1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080213775-A1 | METHODS AND MATERIALS FOR IDENTIFYING POLYMORPHIC VARIANTS, DIAGNOSING SUSCEPTIBILITIES, AND TREATING DISEASE | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND (US) | 2008-09-04 | — | — | US | disclosed |
| WO-2007001259-A1 | METHODS AND MATERIALS FOR IDENTIFYING POLYMORPHIC VARIANTS, DIAGNOSING SUSCEPTIBILITIES, AND TREATING DISEASE | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2001056385-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 2001-08-09 | — | — | WO | disclosed |
| US-6121195-A | STIMULATING CARBON FIXATION AND INCREASING THE GROWTH OF PLANTS BY ENHANCING THE AVAILABILITY OF C1-TETRAHYDROFOLATE IN THE LEAVES OF A PLANT | NONOMURA ARTHUR M (US) | 2000-09-19 | — | — | US | disclosed |
| US-5846908-A | Methods and compositions for enhancing plant growth with p-amino- or p-nitro-benzoic acids | NONOMURA ARTHUR M (US) | 1998-12-08 | — | — | US | disclosed |