Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPGS | Q05932 | 1/20 | 0.41 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.36 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.35 |
| ▸ | ATIC | P31939 | 4/20 | 0.35 |
| ▸ | GART | P22102 | 7/20 | 0.34 |
| ▸ | FOLR1 | P15328 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3195061 | 0.95 | MTHFD1 (0.44) | MTHFD1DHFRMTHFD2SOSTATIC | |
| SCHEMBL17560322 | 0.85 | NOS1 (0.32) | MTHFD1DHFR | |
| SCHEMBL5064786 | 0.85 | DHFR (0.46) | MTHFD1DHFRMTHFD2SOSTATIC | |
| SCHEMBL4616964 | 0.79 | MTHFD1 (0.47) | MTHFD1DHFRMTHFD2SOSTATIC | |
| Leucovorin SCHEMBL1259919 | 0.74 | DHFR (0.71) | FPGSMTHFD1DHFRMTHFD2SOST | |
| SCHEMBL17097094 | 0.72 | MTHFD1 (0.63) | MTHFD1DHFRMTHFD2SOSTATIC | |
| SCHEMBL2166341 | 0.72 | MTHFD1 (0.63) | MTHFD1DHFRMTHFD2SOSTATIC | |
| SCHEMBL2906514 | 0.72 | TYMS (0.62) | DHFRATICGART | |
| SCHEMBL16085830 | 0.71 | MTHFD1 (0.55) | FPGSMTHFD1DHFRMTHFD2SOST | |
| SCHEMBL14843581 | 0.69 | DHFR (0.46) | MTHFD1DHFRMTHFD2SOSTATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579806-B1 | MEDICAMENT FOR THE TREATMENT AND/OR PROPHYLAXIS OF FOLATE METABOLISM DISORDERS | KRAGLER PETER (DE) | 1999-07-07 | — | — | EP | disclosed |
| EP-0579806-A1 | MEDICAMENT FOR THE TREATMENT AND/OR PROPHYLAXIS OF FOLATE METABOLISM DISORDERS | WALDTHALER, Urban (DE) | 1994-01-26 | — | — | EP | disclosed |
| WO-1993015738-A1 | MEDICAMENT FOR THE TREATMENT AND/OR PROPHYLAXIS OF FOLATE METABOLISM DISORDERS | WALDTHALER URBAN (DE) | 1993-08-19 | — | — | WO | disclosed |