Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | GOT1 | P17174 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SOD1 | P00441 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072223 | 0.86 | BCAT2 (0.49) | ALDH1A1HPGDSMN1; SMN2KDM4EHIF1A | |
| SCHEMBL5069647 | 0.84 | HIF1A (0.47) | ALDH1A1HPGDSMN1; SMN2KDM4EHIF1A | |
| SCHEMBL5069668 | 0.81 | HIF1A (0.44) | ALDH1A1HPGDSMN1; SMN2KDM4EHIF1A | |
| SCHEMBL5067187 | 0.77 | EGFR (0.52) | ALDH1A1HPGDSMN1; SMN2KDM4EHIF1A | |
| SCHEMBL4986819 | 0.74 | CSNK2A1 (0.51) | ALDH1A1HPGDKMT2ANPSR1MEN1 | |
| SCHEMBL4990576 | 0.74 | CSNK2A1 (0.54) | ALDH1A1HPGDKMT2ANPSR1MEN1 | |
| SCHEMBL714379 | 0.73 | EGFR (0.61) | SMN1; SMN2KDM4EHIF1ARPS6KB1AURKA | |
| SCHEMBL1863835 | 0.71 | POLB (0.57) | ALDH1A1HPGDSMN1; SMN2KDM4EHIF1A | |
| SCHEMBL14830351 | 0.71 | HIF1A (0.81) | ALDH1A1SMN1; SMN2HIF1ARAB9AHTT | |
| Bicarbonate SCHEMBL11022555 | 0.70 | GOT1 (0.52) | ALDH1A1HPGDSMN1; SMN2KDM4EGOT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | claimed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | claimed |
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | disclosed |