Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 10/20 | 0.41 |
| ▸ | AURKA | O14965 | 9/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5067327 | 0.81 | ALDH1A1 (0.49) | HIF1ARPS6KB1AURKAAURKBKDM5B | |
| SCHEMBL5069647 | 0.81 | HIF1A (0.47) | HIF1ARPS6KB1AURKAAURKBKDM5B | |
| SCHEMBL4997771 | 0.76 | CSNK2A1 (0.51) | HIF1ARPS6KB1KDM5BMEN1KMT2A | |
| SCHEMBL5067187 | 0.74 | EGFR (0.52) | HIF1ARPS6KB1AURKAAURKBKDM5B | |
| SCHEMBL1863835 | 0.72 | POLB (0.57) | HIF1AMEN1KMT2AHPGDKDM4E | |
| SCHEMBL714379 | 0.70 | EGFR (0.61) | HIF1ARPS6KB1AURKAAURKBMEN1 | |
| SCHEMBL5072223 | 0.68 | BCAT2 (0.49) | HIF1ARPS6KB1AURKAMEN1KMT2A | |
| SCHEMBL14830351 | 0.68 | HIF1A (0.81) | HIF1ASMN1; SMN2FOLH1HTTALDH1A1 | |
| SCHEMBL9567555 | 0.67 | HPGD (0.63) | HIF1AMEN1KMT2AHPGDKDM4E | |
| SCHEMBL3130427 | 0.66 | HIF1A (0.54) | HIF1AKMT2AHPGDKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | claimed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | claimed |