Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5067327 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDSMN1; SMN2HIF1A | |
| SCHEMBL2459765 | 0.74 | PPARG (0.49) | ALDH1A1HPGDHTTAURKARPS6KB1 | |
| SCHEMBL1193435 | 0.71 | BCAT2 (0.72) | BCAT2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL5069647 | 0.71 | HIF1A (0.47) | ALDH1A1KDM4EHPGDSMN1; SMN2HIF1A | |
| SCHEMBL5069668 | 0.68 | HIF1A (0.44) | ALDH1A1KDM4EHPGDSMN1; SMN2HIF1A | |
| SCHEMBL19259498 | 0.68 | BCAT2 (0.72) | BCAT2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2459861 | 0.67 | JAK2 (0.53) | ALDH1A1KDM4EHPGDSMN1; SMN2HTT | |
| SCHEMBL27819009 | 0.67 | BCAT2 (0.70) | BCAT2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL18397802 | 0.67 | BCAT2 (0.70) | BCAT2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL10338919 | 0.67 | GOT1 (0.61) | ALDH1A1KDM4EHPGDSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | claimed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | claimed |
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | disclosed |