Isosakutanetin

Isosakutanetin

SCHEMBL5067423

COc1ccc(C2CC(=O)c3c(O)cc(O)cc3O2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 6/20 1.00
CYP1A2 P05177 6/20 1.00
CYP1B1 Q16678 6/20 1.00
CYP19A1 P11511 7/20 0.80
MAPT P10636 4/20 0.80
ALDH1A1 P00352 3/20 0.80
TDP1 Q9NUW8 2/20 0.80
ATM Q13315 2/20 0.80
ADORA3 P0DMS8 1/20 0.80
TAS2R31 P59538 1/20 0.80
CYP3A4 P08684 6/20 0.76
CYP2C19 P33261 4/20 0.76
HSD17B10 Q99714 4/20 0.76
CYP2C9 P11712 3/20 0.76
CA12 O43570 3/20 0.76
CA4 P22748 3/20 0.76
CA7 P43166 3/20 0.76
DPP4 P27487 2/20 0.76
GSK3B P49841 2/20 0.76
MEN1 O00255 2/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isosakutanetin SCHEMBL31128790 1.00 CYP1A1 (1.00) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
Isosakutanetin SCHEMBL676015 1.00 CYP1A1 (1.00) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
Isosakutanetin SCHEMBL29358328 1.00 CYP1A1 (1.00) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
SCHEMBL16710297 0.94 CYP19A1 (0.90) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
SCHEMBL16710295 0.94 CYP19A1 (0.90) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
Isosakutanetin SCHEMBL2146746 0.90 CYP1A1 (0.82) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
Naringenin SCHEMBL7668757 0.90 CYP1A1 (0.82) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
SCHEMBL13906136 0.89 CYP1A1 (0.80) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
Alpinetin SCHEMBL30741428 0.89 CYP1A1 (0.80) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
Alpinetin SCHEMBL29580312 0.89 CYP1A1 (0.80) CYP1A1CYP1A2CYP1B1CYP19A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4617293-A Flavonoid phosphate salts of aminoglycoside antibiotics MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1986-10-14 US claimed
US-20200085956-A1 NOVEL ANTIOXIDANTS FOR COSMETICS AND PHARMACEUTICAL COMPOSITIONS CONTAINING GLYCEROL ALKYL ETHERS SACHEM, INC. 2020-03-19 US disclosed
US-10435673-B2 Method for the biotechnological production of flavonoids SYMRISE AG (DE) 2019-10-08 US disclosed
WO-2018125734-A1 NOVEL ANTIOXIDANTS FOR COSMETICS AND PHARMACEUTICAL COMPOSITIONS CONTAINING GLYCEROL ALKYL ETHERS SACHEM, INC. (US) 2018-07-05 WO disclosed
US-20180135029-A1 METHOD FOR THE BIOTECHNOLOGICAL PRODUCTION OF FLAVONOIDS SYMRISE AG (DE) 2018-05-17 US disclosed
US-20180135029-A1 METHOD FOR THE BIOTECHNOLOGICAL PRODUCTION OF FLAVONOIDS SYMRISE AG (DE) 2018-05-17 US disclosed
US-9415034-B2 Inhibitors and enhancers of uridine diphosphate-glucuronosyltransferase 2B (UGT2B) NATIONAL DEFENSE MEDICAL CENTER (TW) 2016-08-16 US disclosed
US-20160184298-A1 INHIBITORS AND ENHANCERS OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE 2B (UGT2B) NAT DEFENSE MEDICAL CT (TW) 2016-06-30 US disclosed
EP-3002335-A1 Process for the biotechnological production of flavonoids Symrise AG (DE) 2016-04-06 EP disclosed
EP-2984077-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE Chromocell Corporation (US) 2016-02-17 EP disclosed
WO-2006020163-A1 SKIN CARE COMPOSITION CONTAINING A FLAVONOID AND VITAMIN B3 THE PROCTER & GAMBLE COMPANY (US) 2006-02-23 WO disclosed
US-20060018861-A1 Skin care composition PROCTER & GAMBLE COMPANY, THE 2006-01-26 US disclosed
US-20060018858-A1 Skin care composition THE PROCTER & GAMBLE COMPANY 2006-01-26 US disclosed
US-20060018860-A1 Skin care composition PROCTER & GAMBLE COMPANY, THE 2006-01-26 US disclosed
US-20060018862-A1 Substrate based skin care device PROCTER & GAMBLE COMPANY, THE 2006-01-26 US disclosed
EP-1286706-A2 GAMMA IRRADIATION OF PROTEIN-BASED PHARMACEUTICAL PRODUCTS The American National Red Cross (US) 2003-03-05 EP disclosed
WO-2001087357-A2 GAMMA IRRADIATION OF PROTEIN-BASED PHARMACEUTICAL PRODUCTS THE AMERICAN NATIONAL RED CROSS (US) 2001-11-22 WO disclosed
US-4617293-A Flavonoid phosphate salts of aminoglycoside antibiotics MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1986-10-14 US disclosed
EP-0065123-B1 HARDLY SOLUBLE SALTS OF AMINOGLYCOSIDE ANTIBIOTICS MERCK PATENT GmbH (DE) 1984-07-25 EP disclosed
EP-0065123-A1 Hardly soluble salts of aminoglycoside antibiotics MERCK PATENT GmbH (DE) 1982-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060018860-A1 Skin care composition CUTA, C1QBP, FLNB CYP1A1 321/4885CYP1A2 823/4885CYP1B1 69/4885
US-20200085956-A1 NOVEL ANTIOXIDANTS FOR COSMETICS AND PHARMACEUTICAL COMPOSITIONS CONTAINING GLYCEROL ALKYL ETHERS ACOX3, GK, ACAD10 CYP1A1 581/4885CYP1A2 829/4885CYP1B1 508/4885
US-20060018862-A1 Substrate based skin care device CUTA, TYR, PROC CYP1A1 128/4885CYP1A2 334/4885CYP1B1 120/4885
US-20160184298-A1 INHIBITORS AND ENHANCERS OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE 2B (UGT2B) UGT2B7, UGT2B17, UGT1A10 CYP1A1 28/4885CYP1A2 26/4885CYP1B1 16/4885
US-20060018858-A1 Skin care composition CUTA, FLNB, CYP24A1 CYP1A1 252/4885CYP1A2 417/4885CYP1B1 41/4885
US-20060018861-A1 Skin care composition CUTA, SERPINB6, FLNB CYP1A1 381/4885CYP1A2 666/4885CYP1B1 62/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.