Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5070534 | 0.79 | ECE1 (0.48) | ATMCTSSCTSLCTSBCTSK | |
| SCHEMBL5070528 | 0.74 | ECE1 (0.48) | ATMCTSSCTSLCTSBCTSK | |
| SCHEMBL5135601 | 0.74 | ECE1 (0.48) | ATMCTSSCTSLCTSBCTSK | |
| SCHEMBL5069554 | 0.73 | ECE1 (0.48) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL5041973 | 0.73 | ALDH1A1 (0.49) | ATMCTSSCTSLCTSBCTSK | |
| SCHEMBL5071371 | 0.72 | ECE1 (0.55) | ECE1 | |
| SCHEMBL5134614 | 0.71 | ECE1 (0.51) | ECE1MMP8MMP14 | |
| SCHEMBL4420859 | 0.71 | REN (0.67) | ATMRENCTSSCTSLCTSB | |
| SCHEMBL7618822 | 0.71 | REN (0.67) | ATMRENCTSSCTSLCTSB | |
| SCHEMBL2173588 | 0.71 | REN (0.67) | ATMRENCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685142-B1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |