Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5074055 | 0.80 | CHRM2 (0.38) | LMNA | |
| SCHEMBL28393356 | 0.78 | TDP1 (0.39) | LMNAACHETDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11734144 | 0.77 | TDP1 (0.41) | LMNAACHETDP1MEN1KMT2A | |
| SCHEMBL5139533 | 0.72 | RAB9A (0.38) | LMNAACHETDP1KMT2AGPR35 | |
| SCHEMBL28298086 | 0.71 | GPR35 (0.36) | LMNAACHETDP1GPR35ALDH1A1 | |
| Bromide SCHEMBL11733192 | 0.71 | SMN1; SMN2 (0.37) | LMNAACHETDP1MEN1KMT2A | |
| SCHEMBL5509835 | 0.69 | ALDH1A1 (0.37) | LMNAACHETDP1GPR35ALDH1A1 | |
| SCHEMBL20120194 | 0.69 | TDP1 (0.42) | ACHETDP1KMT2AGPR35ALDH1A1 | |
| SCHEMBL29800757 | 0.69 | TDP1 (0.39) | LMNAACHETDP1MEN1KMT2A | |
| SCHEMBL26964204 | 0.69 | TDP1 (0.39) | LMNAACHETDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996585-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109154-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |