Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11733192 | 0.85 | SMN1; SMN2 (0.37) | RAB9AALDH1A1TSHRTAS1R3TAS1R1 | |
| SCHEMBL28298086 | 0.77 | GPR35 (0.36) | RAB9AGPR35ALDH1A1TSHRTAS1R3 | |
| Hydrochloric Acid SCHEMBL11734144 | 0.77 | TDP1 (0.41) | GPR35ALDH1A1TSHRTAS1R3TAS1R1 | |
| SCHEMBL28393356 | 0.76 | TDP1 (0.39) | GPR35ALDH1A1TSHRTAS1R3TAS1R1 | |
| SCHEMBL5509835 | 0.75 | ALDH1A1 (0.37) | RAB9AGPR35ALDH1A1TSHRTAS1R3 | |
| SCHEMBL5075152 | 0.75 | ALDH1A1 (0.51) | RAB9AALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL5073994 | 0.72 | LMNA (0.36) | GPR35ALDH1A1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL27762971 | 0.67 | ALDH1A1 (0.36) | GPR35ALDH1A1TSHRTDP1KMT2A | |
| SCHEMBL11817643 | 0.66 | TDP1 (0.45) | RAB9AGPR35ALDH1A1TSHRACHE | |
| SCHEMBL9234314 | 0.66 | TDP1 (0.44) | GPR35ALDH1A1TSHRTAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933622-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007109192-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |