Sibrafiban

Sibrafiban

SCHEMBL50759

CCOC(=O)COC1CCN(C(=O)[C@H](C)NC(=O)c2ccc(/C(N)=N/O)cc2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 10/20 1.00
ITGA2B P08514 10/20 1.00
F2 P00734 1/20 0.41
LMNA P02545 1/20 0.40
POLB P06746 1/20 0.39
SMYD3 Q9H7B4 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sibrafiban SCHEMBL27618015 1.00 ITGB3 (1.00) ITGB3ITGA2BF2LMNAPOLB
SCHEMBL6947214 0.88 ITGB3 (1.00) ITGB3ITGA2BPOLB
SCHEMBL7285318 0.88 ITGB3 (1.00) ITGB3ITGA2BPOLB
SCHEMBL7285305 0.88 ITGB3 (1.00) ITGB3ITGA2BPOLB
SCHEMBL6947203 0.88 ITGB3 (1.00) ITGB3ITGA2BPOLB
SCHEMBL7284599 0.85 ITGB3 (0.74) ITGB3ITGA2BF2LMNASMYD3
SCHEMBL27544859 0.85 ITGB3 (0.74) ITGB3ITGA2BF2POLBSMYD3
SCHEMBL27403694 0.85 ITGB3 (0.74) ITGB3ITGA2BF2POLBSMYD3
SCHEMBL8645304 0.84 ITGB3 (0.73) ITGB3ITGA2BLMNAPOLBSMYD3
SCHEMBL8379150 0.83 ITGB3 (0.82) ITGB3ITGA2BPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1220 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12584131-B2 Methods of gene therapy OREGON HEALTH & SCIENCE UNIVERSITY (US) 2026-03-24 US claimed
US-12521258-B2 Anticoagulant compounds and methods and devices for their use ELIXIR MEDICAL CORPORATION (US) 2026-01-13 US claimed
EP-4439040-A2 HEPARIN-BASED BLOOD SAMPLER WITHOUT PLATELET ACTIVATION Radiometer Medical ApS (DK) 2024-10-02 EP claimed
EP-3154343-B1 RODENT BAIT CONTAINING TWO OR MORE ANTICOAGULATING COMPOUNDS GULBA DIETRICH (DE) 2023-10-25 EP claimed
US-20230190499-A1 ANTICOAGULANT COMPOUNDS AND METHODS AND DEVICES FOR THEIR USE ELIXIR MEDICAL CORPORATION (US) 2023-06-22 US claimed
US-11421234-B2 Aptamers for targeting coagulation factor XIII and uses thereof CHANG GUNG UNIVERSITY (TW) 2022-08-23 US claimed
US-20210163945-A1 APTAMERS FOR TARGETING COAGULATION FACTOR XIII AND USES THEREOF CHANG GUNG UNIVERSITY (TW) 2021-06-03 US claimed
US-20200393345-A1 HEPARIN-BASED BLOOD SAMPLER WITHOUT PLATELET ACTIVATION RADIOMETER MEDICAL APS (DK) 2020-12-17 US claimed
EP-3710806-A1 HEPARIN-BASED BLOOD SAMPLER WITHOUT PLATELET ACTIVATION Radiometer Medical ApS (DK) 2020-09-23 EP claimed
EP-2214573-B1 SYSTEM FOR TREATMENT AND IMAGING USING ULTRASONIC ENERGY AND MICROBUBBLES UNIV VIRGINIA PATENT FOUNDATION (US) 2019-07-03 EP claimed
WO-2002058734-A2 COMBINATIONS OF STEROL ABSORPTION INHIBITOR(S) WITH BLOOD MODIFIER(S) FOR TREATING VASCULAR CONDITIONS SCHERING CORPORATION (US) 2002-08-01 WO claimed
US-20020068719-A1 Synergy between low molecular weight heparin and platelet aggregation inhibitors, providing a combination therapy for the prevention and treatment of various thromboembolic disorders BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-06-06 US claimed
EP-1189663-A2 SYNERGY BETWEEN LOW MOLECULAR WEIGHT HEPARIN AND PLATELET AGGREGATION INHIBITORS, FOR PREVENTING AND TREATING THROMBOEMBOLIC DISORDERS Du Pont Pharmaceuticals Company (US) 2002-03-27 EP claimed
US-6346517-B1 ADMINISTERING TINZAPARIN AND ROXIFIBAN BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-02-12 US claimed
US-20010036913-A1 Combination therapy for reducing the risks associated with cardiovascular disease GOULD ROBERT J (US) 2001-11-01 US claimed
US-6251852-B1 SUCH AS ACUTE CORONARY ISCHEMIC SYNDROME AND Q-WAVE MYOCARDIAL INFARCTION, BY ADMINISTERING A 3-HYDROXY-3-METHYLGLUTARYL COENZYME A (HMG-COA) REDUCTASE INHIBITOR IN COMBINATION WITH A PLATELET AGGREGATION INHIBITOR MERCK & CO., INC. 2001-06-26 US claimed
US-6235706-B1 Combination therapy for reducing the risks associated with cardiovascular disease MERCK & CO., INC. 2001-05-22 US claimed
WO-2000053168-A2 SYNERGY BETWEEN LOW MOLECULAR WEIGHT HEPARIN AND PLATELET AGGREGATION INHIBITORS, FOR PREVENTING AND TREATING THROMBOEMBOLIC DISORDERS DU PONT PHARMACEUTICALS COMPANY (US) 2000-09-14 WO claimed
EP-0946178-A1 COMBINATION THERAPY FOR REDUCING THE RISKS ASSOCIATED WITH CARDIOVASCULAR DISEASE Merck & Co., Inc. (US) 1999-10-06 EP claimed
WO-1998011896-A1 COMBINATION THERAPY FOR REDUCING THE RISKS ASSOCIATED WITH CARDIOVASCULAR DISEASE MERCK & CO., INC. (US) 1998-03-26 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020068719-A1 Synergy between low molecular weight heparin and platelet aggregation inhibitors, providing a combination therapy for the prevention and treatment of various thromboembolic disorders SERPINC1, SELP, F13B ITGB3 30/4885ITGA2B 20/4885F2 116/4885
US-20010036913-A1 Combination therapy for reducing the risks associated with cardiovascular disease HMGCR, PCSK9, APOB ITGB3 699/4885ITGA2B 740/4885F2 37/4885
US-12584131-B2 Methods of gene therapy CYP7A1, POR, CYP4A22 ITGB3 3772/4885ITGA2B 2294/4885F2 1618/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.